Nucleosome Core Particle with Adducts from the Anticancer Compound, [(eta6-5,8,9,10-tetrahydroanthracene)Ru(ethylenediamine)Cl][PF6]

Summary for 5CP6

DescriptorDNA (145-MER), Histone H3.2, Histone H4, ... (10 entities in total)
Functional Keywordsnucleosome core particle, antitumour compound, structural protein-dna complex, structural protein/dna
Biological sourceXenopus laevis (African clawed frog)
Cellular locationNucleus P84233 P62799 P02281
Total number of polymer chains10
Total molecular weight199584.29
Ma, Z.,Adhireksan, Z.,Murray, B.S.,Dyson, P.J.,Davey, C.A. (deposition date: 2015-07-21, release date: 2016-06-01, Last modification date: 2017-10-04)
Primary citation
Ma, Z.,Palermo, G.,Adhireksan, Z.,Murray, B.S.,von Erlach, T.,Dyson, P.J.,Rothlisberger, U.,Davey, C.A.
An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode.
Angew.Chem.Int.Ed.Engl., 55:7441-7444, 2016
PubMed: 27184539 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201602145
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25270.7%6.9%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution