3CH6
Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone
Summary for 3CH6
Entry DOI | 10.2210/pdb3ch6/pdb |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone, ... (4 entities in total) |
Functional Keywords | 11b-hsd1, sdr, dehydrogenase, hydroxysteroid, inhibitor, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 4 |
Total formula weight | 129664.64 |
Authors | Sheriff, S. (deposition date: 2008-03-07, release date: 2008-06-10, Last modification date: 2024-04-03) |
Primary citation | Wang, H.,Ruan, Z.,Li, J.J.,Simpkins, L.M.,Smirk, R.A.,Wu, S.C.,Hutchins, R.D.,Nirschl, D.S.,Van Kirk, K.,Cooper, C.B.,Sutton, J.C.,Ma, Z.,Golla, R.,Seethala, R.,Salyan, M.E.,Nayeem, A.,Krystek, S.R.,Sheriff, S.,Camac, D.M.,Morin, P.E.,Carpenter, B.,Robl, J.A.,Zahler, R.,Gordon, D.A.,Hamann, L.G. Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 Bioorg.Med.Chem.Lett., 18:3168-3172, 2008 Cited by PubMed: 18485702DOI: 10.1016/j.bmcl.2008.04.069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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