5AGT
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
Summary for 5AGT
Entry DOI | 10.2210/pdb5agt/pdb |
Related | 5AGR 5AGS |
Descriptor | LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ... (5 entities in total) |
Functional Keywords | ligase, leucine-trna ligase activity, atp + l- leucine + trna(leu) gives amp + diphosphate + l-leucyl- trna(leu) aminoacyl-trna editing activity, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Cellular location | Cytoplasm : P9WFV1 |
Total number of polymer chains | 1 |
Total formula weight | 25699.72 |
Authors | Palencia, A.,Li, X.,Alley, M.R.K.,Ding, C.,Easom, E.E.,Hernandez, V.,Meewan, M.,Mohan, M.,Rock, F.L.,Franzblau, S.G.,Wang, Y.,Lenaerts, A.J.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J. (deposition date: 2015-02-03, release date: 2016-03-02, Last modification date: 2024-01-10) |
Primary citation | Palencia, A.,Li, X.,Bu, W.,Choi, W.,Ding, C.Z.,Easom, E.E.,Feng, L.,Hernandez, V.,Houston, P.,Liu, L.,Meewan, M.,Mohan, M.,Rock, F.L.,Sexton, H.,Zhang, S.,Zhou, Y.,Wan, B.,Wang, Y.,Franzblau, S.G.,Woolhiser, L.,Gruppo, V.,Lenaerts, A.J.,O'Malley, T.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Ioerger, T.R.,Sacchettini, J.C.,Rullas, J.,Angulo-Barturen, I.,Perez-Herran, E.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J.,Alley, M.R.K. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:6271-, 2016 Cited by PubMed: 27503647DOI: 10.1128/AAC.01339-16 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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