Author results

3JSZ
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LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1 N293A WITH UDP-GLC
分子名称:Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE, MAGNESIUM ION
著者Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O.
登録日2009-09-11
公開日2010-02-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
3JT1
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LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1, UDP-BOUND FORM
分子名称:Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE
著者Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O.
登録日2009-09-11
公開日2010-02-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
5UOW
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TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5
分子名称:N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ...
著者Lu, W., Du, J., Goehring, A., Gouaux, E.
登録日2017-02-01
公開日2017-03-22
最終更新日2018-10-24
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
5UP2
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TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, RO 25-6981, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5
分子名称:N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ...
著者Lu, W., Du, J., Goehring, A., Gouaux, E.
登録日2017-02-01
公開日2017-03-22
最終更新日2017-11-08
実験手法ELECTRON MICROSCOPY (6 Å)
主引用文献Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
6CUD
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STRUCTURE OF THE HUMAN TRPC3 IN A LIPID-OCCUPIED, CLOSED STATE
分子名称:Short transient receptor potential channel 3, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (2R)-3-hydroxypropane-1,2-diyl dihexanoate, ...
著者Lu, W., Du, J., Fan, C., Choi, W.
登録日2018-03-25
公開日2018-05-16
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018
6UIV
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CRYO-EM STRUCTURE OF HUMAN CALHM2 IN AN ACTIVE/OPEN STATE
分子名称:Calcium homeostasis modulator protein 2
著者Lu, W., Du, J., Choi, W.
登録日2019-10-01
公開日2019-11-27
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6UIW
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CRYO-EM STRUCTURE OF HUMAN CALHM2 IN A RUTHENIUM RED-BOUND INHIBITED STATE
分子名称:Calcium homeostasis modulator protein 2, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
著者Lu, W., Du, J., Choi, W.
登録日2019-10-01
公開日2019-11-27
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6UIX
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CRYO-EM STRUCTURE OF HUMAN CALHM2 GAP JUNCTION
分子名称:Calcium homeostasis modulator protein 2
著者Lu, W., Du, J., Choi, W.
登録日2019-10-01
公開日2019-11-27
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6WBF
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CRYO-EM STRUCTURE OF WILD TYPE HUMAN PANNEXIN 1 CHANNEL
分子名称:Pannexin-1, PHOSPHATIDYLETHANOLAMINE, DI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBG
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL WITH ITS C-TERMINAL TAIL CLEAVED BY CASPASE-7
分子名称:Pannexin-1, PHOSPHATIDYLETHANOLAMINE, DI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBI
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL WITH ITS C-TERMINAL TAIL CLEAVED BY CASPASE-7, IN COMPLEX WITH CBX
分子名称:Pannexin-1, CARBENOXOLONE
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (4.39 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBK
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL WITH DELETION OF N-TERMINAL HELIX AND C-TERMINAL TAIL
分子名称:Pannexin-1
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (6.01 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBL
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL WITH DELETION OF N-TERMINAL HELIX AND C-TERMINAL TAIL, IN COMPLEX WITH CBX
分子名称:Pannexin-1, CARBENOXOLONE
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (5.13 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBM
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL N255A MUTANT
分子名称:Pannexin-1, PHOSPHATIDYLETHANOLAMINE, DI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
6WBN
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CRYO-EM STRUCTURE OF HUMAN PANNEXIN 1 CHANNEL N255A MUTANT, GAP JUNCTION
分子名称:Pannexin-1, PHOSPHATIDYLETHANOLAMINE, DI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Lu, W., Du, J., Ruan, Z.
登録日2020-03-26
公開日2020-06-03
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 2020
2FDP
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CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO-ETHYLENE INHIBITOR
分子名称:Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE
著者Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D.
登録日2005-12-14
公開日2006-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
2ZJK
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CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE
分子名称:Beta-secretase 1, (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
著者Randal, M., Lam, M.B., Lu, W., Romanowski, M.J.
登録日2008-03-07
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
2ZJL
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CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-BROMO-2,3-DIMETHOXY-BENZYL)-PIPERIDIN-4-YL]-4-MERCAPTO-BUTYRAMIDE
分子名称:Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
著者Randal, M., Lam, M.B., Lu, W., Romanowski, M.J.
登録日2008-03-07
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
3H6C
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (MUTANT GLN22ALA)
分子名称:Neutrophil defensin 1, DI(HYDROXYETHYL)ETHER, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2009-04-23
公開日2010-03-09
最終更新日2011-08-17
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3HJ2
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CRYSTAL STRUCTURE OF COVALENT DIMER OF HNP1
分子名称:HUMAN NEUTROPHIL PEPTIDE 1
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2009-05-20
公開日2009-10-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1?
To be Published
3HJD
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X-RAY STRUCTURE OF MONOMERIC VARIANT OF HNP1
分子名称:Human neutrophil peptide 1
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2009-05-21
公開日2009-10-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP?
To be Published
3IWY
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CRYSTAL STRUCTURE OF HUMAN MDM2 COMPLEXED WITH D-PEPTIDE (12 RESIDUES)
分子名称:D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
著者Pazgier, M., Lu, W.
登録日2009-09-03
公開日2010-04-21
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3LNZ
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CRYSTAL STRUCTURE OF HUMAN MDM2 WITH A 12-MER PEPTIDE INHIBITOR PMI (N8A MUTANT)
分子名称:E3 ubiquitin-protein ligase Mdm2, 12-mer peptide inhibitor, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
J.Mol.Biol., 398, 2010
3LO1
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y16A MUTANT)
分子名称:Neutrophil defensin 1, 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO2
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y21A MUTANT)
分子名称:Neutrophil defensin 1, (4S)-2-METHYL-2,4-PENTANEDIOL, trifluoroacetic acid, ...
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010