Author results

3JSZ
  • Download 3jsz
  • View 3jsz
Molmil generated image of 3jsz
LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1 N293A WITH UDP-GLC
分子名称:Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE, MAGNESIUM ION
著者Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O.
登録日2009-09-11
公開日2010-02-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
3JT1
  • Download 3jt1
  • View 3jt1
Molmil generated image of 3jt1
LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1, UDP-BOUND FORM
分子名称:Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE
著者Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O.
登録日2009-09-11
公開日2010-02-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
5UOW
  • Download 5uow
  • View 5uow
Molmil generated image of 5uow
TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5
分子名称:N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ...
著者Lu, W., Du, J., Goehring, A., Gouaux, E.
登録日2017-02-01
公開日2017-03-22
最終更新日2018-10-24
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
5UP2
  • Download 5up2
  • View 5up2
Molmil generated image of 5up2
TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, RO 25-6981, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5
分子名称:N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ...
著者Lu, W., Du, J., Goehring, A., Gouaux, E.
登録日2017-02-01
公開日2017-03-22
最終更新日2017-11-08
実験手法ELECTRON MICROSCOPY (6 Å)
主引用文献Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
6CUD
  • Download 6cud
  • View 6cud
Molmil generated image of 6cud
STRUCTURE OF THE HUMAN TRPC3 IN A LIPID-OCCUPIED, CLOSED STATE
分子名称:Short transient receptor potential channel 3, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (2R)-3-hydroxypropane-1,2-diyl dihexanoate, ...
著者Lu, W., Du, J., Fan, C., Choi, W.
登録日2018-03-25
公開日2018-05-16
最終更新日2018-05-23
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018
2FDP
  • Download 2fdp
  • View 2fdp
Molmil generated image of 2fdp
CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO-ETHYLENE INHIBITOR
分子名称:Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE
著者Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D.
登録日2005-12-14
公開日2006-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
2ZJK
  • Download 2zjk
  • View 2zjk
Molmil generated image of 2zjk
CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE
分子名称:Beta-secretase 1, (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
著者Randal, M., Lam, M.B., Lu, W., Romanowski, M.J.
登録日2008-03-07
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
2ZJL
  • Download 2zjl
  • View 2zjl
Molmil generated image of 2zjl
CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-BROMO-2,3-DIMETHOXY-BENZYL)-PIPERIDIN-4-YL]-4-MERCAPTO-BUTYRAMIDE
分子名称:Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
著者Randal, M., Lam, M.B., Lu, W., Romanowski, M.J.
登録日2008-03-07
公開日2009-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
3H6C
  • Download 3h6c
  • View 3h6c
Molmil generated image of 3h6c
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (MUTANT GLN22ALA)
分子名称:Neutrophil defensin 1, DI(HYDROXYETHYL)ETHER, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2009-04-23
公開日2010-03-09
最終更新日2011-08-17
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3HJ2
  • Download 3hj2
  • View 3hj2
Molmil generated image of 3hj2
CRYSTAL STRUCTURE OF COVALENT DIMER OF HNP1
分子名称:HUMAN NEUTROPHIL PEPTIDE 1
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2009-05-20
公開日2009-10-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1?
To be Published
3HJD
  • Download 3hjd
  • View 3hjd
Molmil generated image of 3hjd
X-RAY STRUCTURE OF MONOMERIC VARIANT OF HNP1
分子名称:Human neutrophil peptide 1
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2009-05-21
公開日2009-10-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP?
To be Published
3IWY
  • Download 3iwy
  • View 3iwy
Molmil generated image of 3iwy
CRYSTAL STRUCTURE OF HUMAN MDM2 COMPLEXED WITH D-PEPTIDE (12 RESIDUES)
分子名称:D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
著者Pazgier, M., Lu, W.
登録日2009-09-03
公開日2010-04-21
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3LNZ
  • Download 3lnz
  • View 3lnz
Molmil generated image of 3lnz
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH A 12-MER PEPTIDE INHIBITOR PMI (N8A MUTANT)
分子名称:E3 ubiquitin-protein ligase Mdm2, 12-mer peptide inhibitor, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
J.Mol.Biol., 398, 2010
3LO1
  • Download 3lo1
  • View 3lo1
Molmil generated image of 3lo1
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y16A MUTANT)
分子名称:Neutrophil defensin 1, 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO2
  • Download 3lo2
  • View 3lo2
Molmil generated image of 3lo2
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y21A MUTANT)
分子名称:Neutrophil defensin 1, (4S)-2-METHYL-2,4-PENTANEDIOL, trifluoroacetic acid, ...
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO4
  • Download 3lo4
  • View 3lo4
Molmil generated image of 3lo4
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (R24A MUTANT)
分子名称:Neutrophil defensin 1, DI(HYDROXYETHYL)ETHER, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-08-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO6
  • Download 3lo6
  • View 3lo6
Molmil generated image of 3lo6
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (W26ABA MUTANT)
分子名称:Neutrophil defensin 1, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO9
  • Download 3lo9
  • View 3lo9
Molmil generated image of 3lo9
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (W26AHP MUTANT)
分子名称:Neutrophil defensin 1
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LOE
  • Download 3loe
  • View 3loe
Molmil generated image of 3loe
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (F28A MUTANT)
分子名称:Neutrophil defensin 1, SULFATE ION, GLYCEROL
著者Pazgier, M., Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LVX
  • Download 3lvx
  • View 3lvx
Molmil generated image of 3lvx
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (I6A MUTANT)
分子名称:Neutrophil defensin 1, SULFATE ION, GLYCEROL
著者Pazgier, M., Lu, W.
登録日2010-02-22
公開日2010-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
1ZMH
  • Download 1zmh
  • View 1zmh
Molmil generated image of 1zmh
CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL PEPTIDE 2, HNP-2 (VARIANT GLY16-> D-ALA)
分子名称:Neutrophil defensin 2, SULFATE ION, HEXAETHYLENE GLYCOL, ...
著者Lubkowski, J., Prahl, A., Lu, W.
登録日2005-05-10
公開日2005-08-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMI
  • Download 1zmi
  • View 1zmi
Molmil generated image of 1zmi
CRYSTAL STRUCTURE OF HUMAN ALPHA_DEFENSIN-2 (VARIANT GLY16->D-ALA), P 32 2 1 SPACE GROUP )
分子名称:Neutrophil defensin 2, GLYCEROL, SULFATE ION
著者Lubkowski, J., Prahl, A., Lu, W.
登録日2005-05-10
公開日2005-08-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMK
  • Download 1zmk
  • View 1zmk
Molmil generated image of 1zmk
CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN-2 (VARIANT GLY16-> D-ALA), P 42 21 2 SPACE GROUP
分子名称:Neutrophil defensin 2, CHLORIDE ION, GLYCEROL
著者Lubkowski, J., Prahl, A., Lu, W.
登録日2005-05-10
公開日2005-08-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
2PLZ
  • Download 2plz
  • View 2plz
Molmil generated image of 2plz
ARG-MODIFIED HUMAN BETA-DEFENSIN 1 (HBD1)
分子名称:Beta-defensin 1, SULFATE ION
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2007-04-20
公開日2007-05-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
J.Biol.Chem., 282, 2007
2PM1
  • Download 2pm1
  • View 2pm1
Molmil generated image of 2pm1
DERIVATIVE OF HUMAN ALPHA-DEFENSIN 1 (HNP1)
分子名称:Neutrophil defensin 1 (HNP-1) (HP-1) (HP1) (Defensin, alpha 1)
著者Lubkowski, J., Pazgier, M., Lu, W.
登録日2007-04-20
公開日2007-05-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Derivative of human alpha-defensin 1 (HNP1)
To be Published