3H6C

Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)

Summary for 3H6C

Entry DOI	10.2210/pdb3h6c/pdb
Related	3GNY 3GO0
Descriptor	Neutrophil defensin 1, DI(HYDROXYETHYL)ETHER, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	antimicrobial peptide, q22a mutant of human alpha defensin 1 q22a mutant of human neutrophil peptide 1, hnp1(q22a), antibiotic, antimicrobial, antiviral defense, defensin, disulfide bond, fungicide, phosphoprotein, secreted, antimicrobial protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P59665
Total number of polymer chains	2
Total formula weight	7108.72
Authors	Pazgier, M.,Lu, W. (deposition date: 2009-04-23, release date: 2010-03-09, Last modification date: 2021-10-27)
Primary citation	Wei, G.,Pazgier, M.,de Leeuw, E.,Rajabi, M.,Li, J.,Zou, G.,Jung, G.,Yuan, W.,Lu, W.Y.,Lehrer, R.I.,Lu, W. Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285:16275-16285, 2010 Cited by PubMed: 20220136 DOI: 10.1074/jbc.M110.102749 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation