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1R5H
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BU of 1r5h by Molmil
Crystal Structure of MetAP2 complexed with A320282
Descriptor: MANGANESE (II) ION, Methionine aminopeptidase 2, N'-(2S,3R)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-BUTANO-N-(4-METHYLPHENYL)HYDRAZIDE
Authors:Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Erickson, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R.
Deposit date:2003-10-10
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R58
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BU of 1r58 by Molmil
Crystal Structure of MetAP2 complexed with A357300
Descriptor: MANGANESE (II) ION, Methionine aminopeptidase 2, N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
Authors:Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Ericken, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R.
Deposit date:2003-10-09
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R5G
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BU of 1r5g by Molmil
Crystal Structure of MetAP2 complexed with A311263
Descriptor: (2S,3R)-3-AMINO-2-HYDROXY-5-(ETHYLSULFANYL)PENTANOYL-((S)-(-)-(1-NAPHTHYL)ETHYL)AMIDE, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Erickson, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R.
Deposit date:2003-10-10
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
8GMH
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BU of 8gmh by Molmil
Crystal Structure of the ternary complex of TelA-LXG, LapA3, and LapA4
Descriptor: 1,2-ETHANEDIOL, LXG domain-containing protein, LapA3, ...
Authors:Klein, T.A, Shah, P.Y, Gkragkopoulou, P, Grebenc, D.W, Kim, Y, Whitney, J.C.
Deposit date:2023-03-25
Release date:2024-01-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a tripartite protein complex that targets toxins to the type VII secretion system.
Proc.Natl.Acad.Sci.USA, 121, 2024
1N9U
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BU of 1n9u by Molmil
Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship
Descriptor: Angiotensin I
Authors:Spyroulias, G.A, Nikolakopoulou, P, Tzakos, A, Gerothanassis, I.P, Magafa, V, Manessi-Zoupa, E, Cordopatis, P.
Deposit date:2002-11-26
Release date:2003-07-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship.
Eur.J.Biochem., 270, 2003
1N9V
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BU of 1n9v by Molmil
Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship.
Descriptor: Angiotensin II
Authors:Spyroulias, G.A, Nikolakopoulou, P, Tzakos, A, Gerothanassis, I.P, Magafa, V, Manessi-Zoupa, E, Cordopatis, P.
Deposit date:2002-11-26
Release date:2003-07-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship.
Eur.J.Biochem., 270, 2003
2EA2
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BU of 2ea2 by Molmil
h-MetAP2 complexed with A773812
Descriptor: 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.H.
Deposit date:2007-01-30
Release date:2008-02-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Bioorg.Med.Chem.Lett., 17, 2007
2EA4
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BU of 2ea4 by Molmil
h-MetAP2 complexed with A797859
Descriptor: 2-(2-AMINOETHOXY)-3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.H.
Deposit date:2007-01-30
Release date:2008-02-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Bioorg.Med.Chem.Lett., 17, 2007
1YW8
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BU of 1yw8 by Molmil
h-MetAP2 complexed with A751277
Descriptor: 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW7
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BU of 1yw7 by Molmil
h-MetAP2 complexed with A444148
Descriptor: 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW9
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BU of 1yw9 by Molmil
h-MetAP2 complexed with A849519
Descriptor: 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
2GA2
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BU of 2ga2 by Molmil
h-MetAP2 complexed with A193400
Descriptor: 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2
Authors:Park, C.
Deposit date:2006-03-07
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Bioorg.Med.Chem.Lett., 16, 2006
1UV5
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BU of 1uv5 by Molmil
GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME
Descriptor: 6-BROMOINDIRUBIN-3'-OXIME, CHLORIDE ION, COBALT (II) ION, ...
Authors:Dajani, R, Pearl, L.H, Roe, S.M.
Deposit date:2004-01-14
Release date:2004-01-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Gsk-3-Selective Inhibitors Derived from Tyrian Purple Indurubins
Chem.Biol., 10, 2003
1K24
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BU of 1k24 by Molmil
Crystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidis
Descriptor: PENTAETHYLENE GLYCOL, ZINC ION, outer membrane protein
Authors:Prince, S.M, Achtman, M, Derrick, J.P.
Deposit date:2001-09-26
Release date:2002-03-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis.
Proc.Natl.Acad.Sci.USA, 99, 2002
8PY3
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BU of 8py3 by Molmil
Crystal structure of human Sirt2 in complex with a 1,2,4-oxadiazole based inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-chloranyl-~{N}-[4-[5-[[(3~{S})-1-[(3-fluoranyl-2-methyl-phenyl)methyl]piperidin-3-yl]methyl]-1,2,4-oxadiazol-3-yl]phenyl]benzamide, ...
Authors:Friedrich, F, Colcerasa, A, Einsle, O, Jung, M.
Deposit date:2023-07-24
Release date:2024-06-19
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2.
J.Med.Chem., 67, 2024
6TH4
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BU of 6th4 by Molmil
Tubulin-inhibitor complex
Descriptor: 1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Varela, P.F, Gigant, B.
Deposit date:2019-11-18
Release date:2021-12-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.121 Å)
Cite:B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
Acs Omega, 7, 2022
6SEQ
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BU of 6seq by Molmil
Lemur tyrosine kinase 3 (LMTK3)
Descriptor: Serine/threonine-protein kinase LMTK3
Authors:Roe, S.M, Owen, R.
Deposit date:2019-07-30
Release date:2020-11-25
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure-function relationship of oncogenic LMTK3.
Sci Adv, 6, 2020
7N4T
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BU of 7n4t by Molmil
Low conductance mechanosensitive channel YnaI
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Low conductance mechanosensitive channel YnaI
Authors:Catalano, C, Ben-Hail, D, Qiu, W, des Georges, A, Guo, Y.
Deposit date:2021-06-04
Release date:2022-04-20
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of Mechanosensitive Channel YnaI Using SMA2000: Challenges and Opportunities.
Membranes (Basel), 11, 2021
1HN2
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BU of 1hn2 by Molmil
CRYSTAL STRUCTURE OF BOVINE OBP COMPLEXED WITH AMINOANTHRACENE
Descriptor: (3R)-oct-1-en-3-ol, ANTHRACEN-1-YLAMINE, ODORANT-BINDING PROTEIN
Authors:Vincent, F, Spinelli, S, Tegoni, M, Cambillau, C.
Deposit date:2000-12-05
Release date:2001-12-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein.
J.Biol.Chem., 276, 2001
3T9N
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BU of 3t9n by Molmil
Crystal structure of a membrane protein
Descriptor: DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel
Authors:Yang, M, Zhang, X, Ge, J, Wang, J.
Deposit date:2011-08-03
Release date:2012-10-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.456 Å)
Cite:Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
3UDC
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BU of 3udc by Molmil
Crystal structure of a membrane protein
Descriptor: Small-conductance mechanosensitive channel, C-terminal peptide from Small-conductance mechanosensitive channel
Authors:Li, W, Ge, J, Yang, M.
Deposit date:2011-10-28
Release date:2012-10-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.355 Å)
Cite:Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
1G85
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BU of 1g85 by Molmil
CRYSTAL STRUCTURE OF BOVINE ODORANT BINDING PROTEIN COMPLEXED WITH IS NATURAL LIGAND
Descriptor: (3R)-oct-1-en-3-ol, ODORANT-BINDING PROTEIN
Authors:Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M.
Deposit date:2000-11-16
Release date:2002-06-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein.
J.Biol.Chem., 276, 2001
2QLU
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BU of 2qlu by Molmil
Crystal structure of Activin receptor type II kinase domain from human
Descriptor: ADENINE, Activin receptor type IIB, SULFATE ION
Authors:Han, S.
Deposit date:2007-07-13
Release date:2007-11-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution
Protein Sci., 16, 2007
2H29
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BU of 2h29 by Molmil
Crystal structure of Nicotinic acid mononucleotide Adenylyltransferase from Staphylococcus aureus: product bound form 1
Descriptor: NICOTINIC ACID ADENINE DINUCLEOTIDE, Probable nicotinate-nucleotide adenylyltransferase
Authors:Han, S.
Deposit date:2006-05-18
Release date:2006-08-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Staphyloccocus aureus: Structural Basis for NaAD Interaction in Functional Dimer.
J.Mol.Biol., 360, 2006
2H2A
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BU of 2h2a by Molmil
Crystal structure of Nicotinic acid mononucleotide adenylyltransferase from Staphylococcus aureus: product bound form 2
Descriptor: CALCIUM ION, GLYCEROL, NICOTINIC ACID ADENINE DINUCLEOTIDE, ...
Authors:Han, S.
Deposit date:2006-05-18
Release date:2006-08-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Staphyloccocus aureus: Structural Basis for NaAD Interaction in Functional Dimer.
J.Mol.Biol., 360, 2006

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