1R58

Crystal Structure of MetAP2 complexed with A357300

Summary for 1R58

Entry DOI	10.2210/pdb1r58/pdb
Related	1r5g 1r5h
Descriptor	Methionine aminopeptidase 2, MANGANESE (II) ION, N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41839.75
Authors	Sheppard, G.S.,Wang, J.,Kawai, M.,BaMaung, N.Y.,Craig, R.A.,Ericken, S.A.,Lynch, L.,Patel, J.,Yang, F.,Searle, X.B.,Lou, P.,Park, C.,Kim, K.H.,Henkin, J.,Lesniewski, R. (deposition date: 2003-10-09, release date: 2004-10-12, Last modification date: 2011-07-13)
Primary citation	Sheppard, G.S.,Wang, J.,Kawai, M.,BaMaung, N.Y.,Craig, R.A.,Erickson, S.A.,Lynch, L.,Patel, J.,Yang, F.,Searle, X.B.,Lou, P.,Park, C.,Kim, K.H.,Henkin, J.,Lesniewski, R. 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg.Med.Chem.Lett., 14:865-868, 2004 Cited by PubMed: 15012983 DOI: 10.1016/j.bmcl.2003.12.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation