1R58

Crystal Structure of MetAP2 complexed with A357300

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Source details	RIGAKU RU200
Temperature [K]	110
Detector technology	CCD
Collection date	2000-09-05
Detector	MARRESEARCH
Wavelength(s)	1.54
Spacegroup name	C 2 2 21
Unit cell lengths	90.179, 99.138, 101.065
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	19.960 - 1.900
Rwork	0.204
R-free	0.24700
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.005
RMSD bond angle	1.300
Data reduction software	DENZO
Data scaling software	SCALEPACK
Phasing software	CNS
Refinement software	CNX (2000)

Data quality characteristics

	Overall
Low resolution limit [Å]	20.000
High resolution limit [Å]	1.900

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP	6	277	isopropyl alcohol, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K