6TH4

Tubulin-inhibitor complex

Summary for 6TH4

• Entry DOI: 10.2210/pdb6th4/pdb
• Descriptor: Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
• Functional Keywords: cytoskeleton, cell division, intracellular transport, transport protein, microtubule, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 5
• Total formula weight: 220489.19

Authors

Varela, P.F.,Gigant, B. (deposition date: 2019-11-18, release date: 2021-12-01, Last modification date: 2024-01-24)

• Primary citation: Stein, A.,Hilken nee Thomopoulou, P.,Frias, C.,Hopff, S.M.,Varela, P.,Wilke, N.,Mariappan, A.,Neudorfl, J.M.,Fedorov, A.Y.,Gopalakrishnan, J.,Gigant, B.,Prokop, A.,Schmalz, H.G.; B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner; Acs Omega, 7:2591-2603, 2022; DOI: 10.1021/acsomega.1c04659

Experimental method

X-RAY DIFFRACTION (2.121 Å)