6TH4

Tubulin-inhibitor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	PRO175
A	LYS394
B	ASN349

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site_id	AC2
Number of Residues	27
Details	binding site for residue GTP A 502

Chain	Residue
A	ASN101
A	SER140
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	VAL177
A	SER178
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	MG503
A	HOH602
A	HOH605
A	HOH607
A	HOH608
A	HOH609
A	HOH616
B	LYS254
A	GLY10
A	GLN11
A	ALA12
A	GLN15
A	ASP98
A	ALA99

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 503

Chain	Residue
A	GTP502
A	HOH602
A	HOH605
A	HOH607
A	HOH608

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 501

Chain	Residue
B	LEU219
B	THR220
B	THR221
C	LYS326

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 B 502

Chain	Residue
B	THR223
B	GLY225
B	ARG278

---

site_id	AC6
Number of Residues	21
Details	binding site for residue GDP B 503

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	SER140
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	PRO173
B	VAL177
B	ASP179
B	GLU183
B	ASN206
B	TYR224
B	ASN228
B	HOH602
B	HOH605
B	HOH606
B	HOH609
B	HOH612

---

site_id	AC7
Number of Residues	16
Details	binding site for residue N9B B 504

Chain	Residue
A	ALA180
A	VAL181
B	VAL238
B	CYS241
B	LEU242
B	LEU248
B	ASN249
B	ALA250
B	ASN258
B	MET259
B	VAL315
B	ALA316
B	ASN350
B	LYS352
B	ILE378
B	HOH611

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 C 501

Chain	Residue
C	ARG215
C	LYS304

---

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 C 502

Chain	Residue
C	ARG390
C	LYS394

---

site_id	AD1
Number of Residues	28
Details	binding site for residue GTP C 503

Chain	Residue
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	HOH606
C	HOH608
C	HOH611
C	HOH612
C	HOH614
C	HOH617
D	LYS254
D	MG501
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP98
C	ALA99
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	ILE171
C	VAL177
C	SER178
C	GLU183

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG D 501

Chain	Residue
C	GTP503
C	HOH611
C	HOH614
D	LYS254

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 D 502

Chain	Residue
D	THR223
D	ARG278
D	PHE404
D	HIS406

---

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 D 503

Chain	Residue
D	LYS19
D	HIS229
D	ARG278

---

site_id	AD5
Number of Residues	24
Details	binding site for residue GDP D 504

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	SER140
D	GLY143
D	GLY144
D	THR145
D	GLY146
D	PRO173
D	VAL177
D	SER178
D	ASP179
D	GLU183
D	ASN206
D	TYR224
D	ASN228
D	HOH604
D	HOH605
D	HOH607
D	HOH610
D	HOH614
D	HOH619
D	HOH624

---

site_id	AD6
Number of Residues	16
Details	binding site for residue N9B D 505

Chain	Residue
C	ASN101
C	ALA180
C	VAL181
D	CYS241
D	LEU242
D	LEU248
D	ALA250
D	ASP251
D	LEU255
D	ASN258
D	MET259
D	VAL315
D	ALA316
D	ASN350
D	LYS352
D	ILE378

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

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site_id	PS00563
Number of Residues	10
Details	STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE

Chain	Residue	Details
E	PRO40-GLU49

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site_id	PS01041
Number of Residues	10
Details	STATHMIN_2 Stathmin family signature 2. AEKREHEREV

Chain	Residue	Details
E	ALA73-VAL82

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
E	SER19

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