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2OH2
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BU of 2oh2 by Molmil
Ternary Complex of Human DNA Polymerase
Descriptor: 5'-D(*GP*GP*G*GP*GP*AP*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*TP*T*CP*CP*AP*GP*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase kappa, ...
Authors:Lone, S, Townson, S.A, Uljon, S.N, Prakash, S, Prakash, L, Aggarwal, A.K.
Deposit date:2007-01-09
Release date:2007-02-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Ternary complex of the catalytic core of human DNA polymerase Kappa with DNA and dTT
To be Published
7ZC9
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BU of 7zc9 by Molmil
Human Pikachurin/EGFLAM C-terminal Laminin-G domain (LG3)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Pikachurin, SULFATE ION
Authors:Pantalone, S, Forneris, F.
Deposit date:2022-03-26
Release date:2023-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
7ZCB
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BU of 7zcb by Molmil
Human Pikachurin/EGFLAM N-terminal Fibronectin-III (1-2) domains
Descriptor: CHLORIDE ION, Pikachurin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Pantalone, S, Savino, S, Viti, L.V, Forneris, F.
Deposit date:2022-03-26
Release date:2023-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
4EEY
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BU of 4eey by Molmil
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ...
Authors:Ummat, A, Rechkoblit, O, Jain, R, Choudhury, J.R, Johnson, R.E, Silverstein, T.D, Buku, A, Lone, S, Prakash, L, Prakash, S, Aggarwal, A.K.
Deposit date:2012-03-28
Release date:2012-05-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.
Nat.Struct.Mol.Biol., 19, 2012
3PZP
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BU of 3pzp by Molmil
Human DNA polymerase kappa extending opposite a cis-syn thymine dimer
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*CP*A)-3', 5'-D(*TP*TP*CP*CP*(TTD)P*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ...
Authors:Vasquez-Del Carpio, R, Silverstein, T.D, Lone, S, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K.
Deposit date:2010-12-14
Release date:2011-12-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.336 Å)
Cite:Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer.
J.Mol.Biol., 408, 2011
3IN5
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BU of 3in5 by Molmil
Structure of human DNA polymerase kappa inserting dATP opposite an 8-oxoG DNA lesion
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*CP*TP*AP*(8OG)P*GP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*G*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*(DOC))-3'), ...
Authors:Silverstein, T.D, Vasquez-Del Carpio, R, Aggarwal, A.K.
Deposit date:2009-08-11
Release date:2009-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of human DNA polymerase kappa inserting dATP opposite an 8-oxoG DNA lesion
PLOS ONE, 4, 2009
3EO1
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BU of 3eo1 by Molmil
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
Descriptor: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3
Authors:Gruetter, C, Gruetter, M.G.
Deposit date:2008-09-26
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EO0
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BU of 3eo0 by Molmil
Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008
Descriptor: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, GLYCEROL
Authors:Gruetter, C, Gruetter, M.G.
Deposit date:2008-09-26
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
6I8G
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BU of 6i8g by Molmil
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB73
Descriptor: EDS1-specific nanobody, Protein EDS1L
Authors:Niefind, K, Voss, M, Toelzer, C.
Deposit date:2018-11-20
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.344 Å)
Cite:Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
J.Struct.Biol., 208, 2019
6I8H
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BU of 6i8h by Molmil
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB15
Descriptor: EDS1-specific nanobody, Protein EDS1L
Authors:Niefind, K, Voss, M, Toelzer, C.
Deposit date:2018-11-20
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.682 Å)
Cite:Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
J.Struct.Biol., 208, 2019
8D1B
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BU of 8d1b by Molmil
CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin
Descriptor: Pikachurin, Probable G-protein coupled receptor 179
Authors:Patil, D.N, Martemyanov, K.A.
Deposit date:2022-05-27
Release date:2023-07-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
5WLV
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BU of 5wlv by Molmil
Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide
Descriptor: 4-{(2R)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}-N-[2-(4-sulfamoylphenyl)ethyl]benzamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
Authors:Lomelino, C.L, Andring, J.T, McKenna, R.
Deposit date:2017-07-27
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
J. Med. Chem., 61, 2018
5WLT
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BU of 5wlt by Molmil
Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
Descriptor: 4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Lomelino, C.L, Andring, J.T, McKenna, R.
Deposit date:2017-07-27
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
J. Med. Chem., 61, 2018
6WQ4
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BU of 6wq4 by Molmil
Carbonic Anhydrase II Complexed with 2-((2-Cyanoethyl)(phenethyl)amino)-N-phenethyl-N-(4-sulfamoylphenethyl)acetamide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R.
Deposit date:2020-04-28
Release date:2020-06-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
J.Med.Chem., 63, 2020
6WQ5
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BU of 6wq5 by Molmil
Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, N~2~-(3-aminopropyl)-N-[(furan-2-yl)methyl]-N~2~-(2-phenylethyl)-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide, ...
Authors:Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R.
Deposit date:2020-04-28
Release date:2020-06-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.304 Å)
Cite:Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
J.Med.Chem., 63, 2020
6WQ9
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BU of 6wq9 by Molmil
Carbonic Anhydrase II Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R.
Deposit date:2020-04-28
Release date:2020-06-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.305 Å)
Cite:Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
J.Med.Chem., 63, 2020
6WQ8
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BU of 6wq8 by Molmil
Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R.
Deposit date:2020-04-28
Release date:2020-06-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.405 Å)
Cite:Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
J.Med.Chem., 63, 2020
6WQ7
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BU of 6wq7 by Molmil
Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, N~2~-(3-aminopropyl)-N-[(4-fluorophenyl)methyl]-N~2~-(2-phenylethyl)-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide, ...
Authors:Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R.
Deposit date:2020-04-28
Release date:2020-06-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.304 Å)
Cite:Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
J.Med.Chem., 63, 2020
6Q6Z
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BU of 6q6z by Molmil
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB21
Descriptor: EDS1-SPECIFIC NANOBODY, Protein EDS1L
Authors:Niefind, K, Voss, M, Toelzer, C.
Deposit date:2018-12-12
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.476 Å)
Cite:Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
J.Struct.Biol., 208, 2019
7ASJ
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BU of 7asj by Molmil
Crystal structure for the complex of human carbonic anhydrase II and 3-(3-methyl-3-phenethylureido)benzenesulfonamide
Descriptor: 3-(3-methyl-3-phenethylureido)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Angeli, A, Ferraroni, M.
Deposit date:2020-10-27
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
J.Med.Chem., 65, 2022
7RNY
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BU of 7rny by Molmil
Carbonic Anhydrase II in complex with 3-ureido benzenesulfonamide derivative
Descriptor: 3-{[benzyl(methyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Combs, J, McKenna, R.
Deposit date:2021-07-30
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
J.Med.Chem., 65, 2022
7RNZ
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BU of 7rnz by Molmil
Carbonic Anhydrase II in complex with 4-ureido benzenesulfonamide derivative
Descriptor: 4-[(methylcarbamoyl)amino]benzene-1-sulfonamide, AZIDE ION, Carbonic anhydrase 2, ...
Authors:Combs, J, McKenna, R.
Deposit date:2021-07-30
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
J.Med.Chem., 65, 2022

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PDB entries from 2024-09-18

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