6WQ7
Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
Summary for 6WQ7
| Entry DOI | 10.2210/pdb6wq7/pdb |
| Descriptor | Carbonic anhydrase 2, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ZINC ION, ... (5 entities in total) |
| Functional Keywords | inhibitor, sulfonamide, caii, ca ii, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 30003.28 |
| Authors | Andring, J.T.,Combs, J.E.,Lomelino, C.,McKenna, R. (deposition date: 2020-04-28, release date: 2020-06-24, Last modification date: 2023-10-18) |
| Primary citation | Bonardi, A.,Nocentini, A.,Bua, S.,Combs, J.,Lomelino, C.,Andring, J.,Lucarini, L.,Sgambellone, S.,Masini, E.,McKenna, R.,Gratteri, P.,Supuran, C.T. Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. J.Med.Chem., 63:7422-7444, 2020 Cited by PubMed: 32519851DOI: 10.1021/acs.jmedchem.0c00733 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.304 Å) |
Structure validation
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