Author results

1FLK
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MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
Descriptor:TNF RECEPTOR ASSOCIATED FACTOR 3
Authors:Ni, C.-Z., Welsh, K., Leo, E., Chiou, C.-K., Wu, H., Reed, J.C., Ely, K.R.
Deposit date:2000-08-14
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FLL
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MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
Descriptor:TNF RECEPTOR ASSOCIATED FACTOR 3, B-CELL SURFACE ANTIGEN CD40
Authors:Ni, C.-Z., Welsh, K., Leo, E., Chiou, C.-K., Wu, H., Reed, J.C., Ely, K.R.
Deposit date:2000-08-14
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
3T8I
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STRUCTURAL ANALYSIS OF THERMOSTABLE S. SOLFATARICUS PURINE-SPECIFIC NUCLEOSIDE HYDROLASE
Descriptor:Purine nucleosidase, (IunH-2), CALCIUM ION, ...
Authors:Minici, C., Cacciapuoti, G., De Leo, E., Porcelli, M., Degano, M.
Deposit date:2011-08-01
Release date:2012-05-16
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus.
Biochemistry, 51, 2012
3T8J
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STRUCTURAL ANALYSIS OF THERMOSTABLE S. SOLFATARICUS PYRIMIDINE-SPECIFIC NUCLEOSIDE HYDROLASE
Descriptor:Purine nucleosidase, (IunH-1), SODIUM ION
Authors:Minici, C., Cacciapuoti, G., De Leo, E., Porcelli, M., Degano, M.
Deposit date:2011-08-01
Release date:2012-05-16
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus.
Biochemistry, 51, 2012
4TT2
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH H4(1-20)K5AC PEPTIDE
Descriptor:ATPase family AAA domain-containing protein 2, Histone H4K5Ac
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TT4
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH H3(1-21)K14AC PEPTIDE
Descriptor:ATPase family AAA domain-containing protein 2, Histone H3(1-21)K4Ac, SULFATE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TT6
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN DOUBLE MUTANT N1063A-Y1064A IN APO FORM
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TTE
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH METHYL 3-AMINO-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)BENZOATE
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-20
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TU4
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH 3-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-5-[(PHENYLSULFONYL)AMINO]BENZOICACID
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, GLYCEROL, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-23
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TU6
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CRYSTAL STRUCTURE OF APO ATAD2A BROMODOMAIN WITH N1064 ALTERNATE CONFORMATION
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-23
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
6EW6
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH ANILINOPYRIMIDINE LIGAND
Descriptor:B-cell lymphoma 6 protein, ~{N}2-(2-chlorophenyl)-1,3,5-triazine-2,4-diamine
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-11-03
Release date:2018-10-24
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem. Biol., 13, 2018
6EW7
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH ANILINOPYRIMIDINE LIGAND
Descriptor:B-cell lymphoma 6 protein, CHLORIDE ION, 2-chloranyl-4-[[5-chloranyl-4-[(4-fluorophenyl)amino]pyrimidin-2-yl]amino]benzoic acid
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-11-03
Release date:2018-10-24
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem. Biol., 13, 2018
6EW8
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH ANILINOPYRIMIDINE LIGAND
Descriptor:B-cell lymphoma 6 protein, CHLORIDE ION, anilinopyrimidine ligand
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-11-03
Release date:2018-10-24
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem. Biol., 13, 2018
4YAB
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH 1-METHYL-5-(2-METHYL-1 3-THIAZOL-4-YL)-2 3-DIHYDRO-1H-INDOL-2-ONE (1)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, 1-methyl-5-(2-methyl-1,3-thiazol-4-yl)-1,3-dihydro-2H-indol-2-one, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-17
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YAD
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH 2,4-DIMETHOXY-N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)BENZENE-1-SULFONAMIDE (3B)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, 2,4-dimethoxy-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-17
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YAT
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-(1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL)-4-METHOXYBENZENE-1-SULFONAMIDE (5B)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-4-methoxybenzenesulfonamide
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-17
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YAX
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-[6-(4-METHOXYPHENOXY)-1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL]BENZENESULFONAMIDE (5G)
Descriptor:Transcription intermediary factor 1-alpha, N-[6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzenesulfonamide, ZINC ION, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-18
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YBM
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-{6-[3-(BENZYLOXY)PHENOXY]-1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL}-3,4-DIMETHOXYBENZENE-1-SULFONAMIDE (7B)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, GLYCEROL, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-18
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YBS
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-{1,3-DIMETHYL-6-[3-(2-METHYLPROPOXY)PHENOXY]-2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL}-1,2-DIMETHYL-1H-IMIDAZOLE-4-SULFONAMIDE (7G)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, N-{1,3-dimethyl-6-[3-(2-methylpropoxy)phenoxy]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-1,2-dimethyl-1H-imidazole-4-sulfonamide, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-19
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YBT
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-{1,3-DIMETHYL-2-OXO-6-[3-(OXOLAN-3-YLMETHOXY)PHENOXY]-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL}-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE (7L)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-19
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
4YC9
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CRYSTAL STRUCTURE OF TRIM24 PHD-BROMODOMAIN COMPLEXED WITH N-(6-{3-[4-(DIMETHYLAMINO)BUTOXY]-5-PROPOXYPHENOXY}-1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL)-3,4-DIMETHOXYBENZENE-1-SULFONAMIDE (8I)
Descriptor:Transcription intermediary factor 1-alpha, ZINC ION, GLYCEROL, ...
Authors:Poncet-Montange, G., Palmer, W., Jones, P.
Deposit date:2015-02-19
Release date:2015-06-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016