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4YC9

Crystal structure of TRIM24 PHD-bromodomain complexed with N-(6-{3-[4-(dimethylamino)butoxy]-5-propoxyphenoxy}-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-3,4-dimethoxybenzene-1-sulfonamide (8i)

Summary for 4YC9
Entry DOI10.2210/pdb4yc9/pdb
Related4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT
DescriptorTranscription intermediary factor 1-alpha, ZINC ION, GLYCEROL, ... (5 entities in total)
Functional Keywordscenter for biomolecular structure and function, bromodomain, trim24, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : O15164
Total number of polymer chains1
Total formula weight22184.07
Authors
Poncet-Montange, G.,Palmer, W.,Jones, P. (deposition date: 2015-02-19, release date: 2015-06-24, Last modification date: 2023-09-27)
Primary citationPalmer, W.S.,Poncet-Montange, G.,Liu, G.,Petrocchi, A.,Reyna, N.,Subramanian, G.,Theroff, J.,Yau, A.,Kost-Alimova, M.,Bardenhagen, J.P.,Leo, E.,Shepard, H.E.,Tieu, T.N.,Shi, X.,Zhan, Y.,Zhao, S.,Barton, M.C.,Draetta, G.,Toniatti, C.,Jones, P.,Geck Do, M.,Andersen, J.N.
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59:1440-1454, 2016
Cited by
PubMed: 26061247
DOI: 10.1021/acs.jmedchem.5b00405
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

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