6EW6

Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand

Summary for 6EW6

Entry DOI	10.2210/pdb6ew6/pdb
Related	5N1X 5N1Z 5N20 5N21
Descriptor	B-cell lymphoma 6 protein, ~{N}2-(2-chlorophenyl)-1,3,5-triazine-2,4-diamine (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14405.08
Authors	Robb, G.,Ferguson, A.,Hargreaves, D. (deposition date: 2017-11-03, release date: 2018-10-24, Last modification date: 2018-11-28)
Primary citation	McCoull, W.,Cheung, T.,Anderson, E.,Barton, P.,Burgess, J.,Byth, K.,Cao, Q.,Castaldi, M.P.,Chen, H.,Chiarparin, E.,Carbajo, R.J.,Code, E.,Cowan, S.,Davey, P.R.,Ferguson, A.D.,Fillery, S.,Fuller, N.O.,Gao, N.,Hargreaves, D.,Howard, M.R.,Hu, J.,Kawatkar, A.,Kemmitt, P.D.,Leo, E.,Molina, D.M.,O'Connell, N.,Petteruti, P.,Rasmusson, T.,Raubo, P.,Rawlins, P.B.,Ricchiuto, P.,Robb, G.R.,Schenone, M.,Waring, M.J.,Zinda, M.,Fawell, S.,Wilson, D.M. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem. Biol., 13:3131-3141, 2018 Cited by PubMed: 30335946 DOI: 10.1021/acschembio.8b00698 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.39 Å)

Structure validation