Author results

5HS7
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REDUCED FORM OF THE TRANSCRIPTIONAL REGULATOR YODB FROM B. SUBTILIS
Descriptor:HTH-type transcriptional regulator YodB, GLYCEROL
Authors:Lee, S.J., Lee, I.G., Lee, B.J.
Deposit date:2016-01-25
Release date:2016-08-17
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two distinct mechanisms of transcriptional regulation by the redox sensor YodB
Proc.Natl.Acad.Sci.USA, 113, 2016
5HS8
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CRYSTAL STRUCTURE OF THE DIAMIDE-TREATED YODB FROM B. SUBTILIS
Descriptor:HTH-type transcriptional regulator YodB
Authors:Lee, S.J., Lee, I.G., Lee, B.J.
Deposit date:2016-01-25
Release date:2016-08-17
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two distinct mechanisms of transcriptional regulation by the redox sensor YodB
Proc.Natl.Acad.Sci.USA, 113, 2016
5HS9
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CRYSTAL STRUCTURE OF THE QUINONE-BOUND YODB FROM B. SUBTILIS
Descriptor:HTH-type transcriptional regulator YodB
Authors:Lee, S.J., Lee, I.G., Lee, B.J.
Deposit date:2016-01-25
Release date:2016-08-17
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two distinct mechanisms of transcriptional regulation by the redox sensor YodB
Proc.Natl.Acad.Sci.USA, 113, 2016
3U7K
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CRYSTAL STRUCTURES OF THE STAPHYLOCOCCUS AUREUS PEPTIDE DEFORMYLASE IN COMPLEX WITH TWO CLASSES OF NEW INHIBITORS
Descriptor:Peptide deformylase, (S)-N-(cyclopentylmethyl)-N-(2-(hydroxyamino)-2-oxoethyl)-2-(3-(2-methoxyphenyl)ureido)-3,3-dimethylbutanamide, ZINC ION
Authors:Lee, S.J., Lee, S.-J., Lee, S.K., Yoon, H.-J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.
Deposit date:2011-10-14
Release date:2012-06-27
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
3U7L
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CRYSTAL STRUCTURES OF THE STAPHYLOCOCCUS AUREUS PEPTIDE DEFORMYLASE IN COMPLEX WITH TWO CLASSES OF NEW INHIBITORS
Descriptor:Peptide deformylase, ZINC ION, (S)-N-(cyclopentylmethyl)-2-(3-(3,5-difluorophenyl)ureido)-N-(2-(hydroxyamino)-2-oxoethyl)-3,3-dimethylbutanamide
Authors:Lee, S.J., Lee, S.-J., Lee, S.K., Yoon, H.-J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.
Deposit date:2011-10-14
Release date:2012-06-27
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
3U7M
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CRYSTAL STRUCTURES OF THE STAPHYLOCOCCUS AUREUS PEPTIDE DEFORMYLASE IN COMPLEX WITH TWO CLASSES OF NEW INHIBITORS
Descriptor:Peptide deformylase, ZINC ION, N-((2R,4S)-2-butyl-4-(3-(2-fluorophenyl)ureido)-5-methyl-3-oxohexyl)-N-hydroxyformamide
Authors:Lee, S.J., Lee, S.-J., Lee, S.K., Yoon, H.-J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.
Deposit date:2011-10-14
Release date:2012-06-27
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
3U7N
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CRYSTAL STRUCTURES OF THE STAPHYLOCOCCUS AUREUS PEPTIDE DEFORMYLASE IN COMPLEX WITH TWO CLASSES OF NEW INHIBITORS
Descriptor:Peptide deformylase, ZINC ION, N-((2R,4S)-2-butyl-5-methyl-4-(3-(5-methylpyridin-2-yl)ureido)-3-oxohexyl)-N-hydroxyformamide
Authors:Lee, S.J., Lee, S.-J., Lee, S.K., Yoon, H.-J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.
Deposit date:2011-10-14
Release date:2012-06-27
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
4Q25
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CRYSTAL STRUCTURE OF PHOU FROM PSEUDOMONAS AERUGINOSA
Descriptor:Phosphate-specific transport system accessory protein PhoU homolog
Authors:Lee, S.J., Lee, B.-J., Suh, S.W.
Deposit date:2014-04-07
Release date:2015-02-18
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of PhoU from Pseudomonas aeruginosa, a negative regulator of the Pho regulon.
J.Struct.Biol., 188, 2014
4JX3
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CRYSTAL STRUCTURE OF PIM1 KINASE
Descriptor:Serine/threonine-protein kinase pim-1
Authors:Lee, S.J., Han, B.G., Cho, J.W., Choi, J.S., Lee, J.K., Song, H.J., Koh, J.S., Lee, B.I.
Deposit date:2013-03-27
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
4JX7
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR 2-[(TRANS-4-AMINOCYCLOHEXYL)AMINO]-4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE
Descriptor:Serine/threonine-protein kinase pim-1, PIM1 consensus peptide, 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one
Authors:Lee, S.J., Han, B.G., Cho, J.W., Choi, J.S., Lee, J.K., Song, H.J., Koh, J.S., Lee, B.I.
Deposit date:2013-03-27
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
5Y5T
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CRYSTAL STRUCTURES OF SPLEEN TYROSINE KINASE IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Tyrosine-protein kinase SYK, 2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one
Authors:Lee, S.J., Lee, B.I.
Deposit date:2017-08-09
Release date:2018-06-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Mol. Cells, 41, 2018
5Y5U
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CRYSTAL STRUCTURES OF SPLEEN TYROSINE KINASE IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Tyrosine-protein kinase SYK, 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one
Authors:Lee, S.J., Lee, B.I.
Deposit date:2017-08-09
Release date:2018-06-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Mol. Cells, 41, 2018
4XG2
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CRYSTAL STRUCTURE OF LIGAND-FREE SYK
Descriptor:Tyrosine-protein kinase SYK
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG3
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG4
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG6
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG7
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG8
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4XG9
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2014-12-30
Release date:2015-12-30
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
5GHV
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CRYSTAL STRUCTURE OF AN INHIBITOR-BOUND SYK
Descriptor:Tyrosine-protein kinase SYK, 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol
Authors:Lee, S.J., Choi, J., Han, B.G., Song, H., Koh, J.S., Lee, B.I.
Deposit date:2016-06-20
Release date:2016-07-06
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
4GAM
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COMPLEX STRUCTURE OF METHANE MONOOXYGENASE HYDROXYLASE AND REGULATORY SUBUNIT
Descriptor:Methane monooxygenase component A beta chain, Methane monooxygenase component A alpha chain, Methane monooxygenase component A gamma chain, ...
Authors:Lee, S.J., Lippard, S.J., Cho, U.-S.
Deposit date:2012-07-25
Release date:2013-02-06
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Control of substrate access to the active site in methane monooxygenase.
Nature, 494, 2013
3QHP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF CHOLESTEROL-ALPHA-GLUCOSYLTRANSFERASE FROM HELICOBACTER PYLORI
Descriptor:Type 1 capsular polysaccharide biosynthesis protein J (CapJ)
Authors:Lee, S.J., Lee, B.I., Suh, S.W.
Deposit date:2011-01-26
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the catalytic domain of cholesterol-alpha-glucosyltransferase from Helicobacter pylori
Proteins, 79, 2011
3NIO
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA GUANIDINOBUTYRASE
Descriptor:Guanidinobutyrase, MANGANESE (II) ION
Authors:Lee, S.J., Kim, H.S., Kim, D.J., Yoon, H.J., Kim, K.H., Yoon, J.Y., Jang, J.Y., Im, H., An, D., Suh, S.W.
Deposit date:2010-06-16
Release date:2011-06-01
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily
J.Struct.Biol., 175, 2011
3NIP
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA GUANIDINOPROPIONASE COMPLEXED WITH 1,6-DIAMINOHEXANE
Descriptor:3-guanidinopropionase, HEXANE-1,6-DIAMINE
Authors:Lee, S.J., Kim, H.S., Kim, D.J., Yoon, H.J., Kim, K.H., Yoon, J.Y., Jang, J.Y., Im, H., An, D., Suh, S.W.
Deposit date:2010-06-16
Release date:2011-06-01
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily
J.Struct.Biol., 175, 2011
3NIQ
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA GUANIDINOPROPIONASE
Descriptor:3-guanidinopropionase, GLYCEROL, MANGANESE (II) ION
Authors:Lee, S.J., Kim, H.S., Kim, D.J., Yoon, H.J., Kim, K.H., Yoon, J.Y., Jang, J.Y., Im, H., An, D., Suh, S.W.
Deposit date:2010-06-16
Release date:2011-06-01
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily
J.Struct.Biol., 175, 2011