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2K5B
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HUMAN CDC37-HSP90 DOCKING MODEL BASED ON NMR
Descriptor:Heat shock protein HSP 90-alpha, Hsp90 co-chaperone Cdc37
Authors:Sreeramulu, S., Jonker, H.R.A., Lancaster, C.R., Richter, C., Langer, T., Schwalbe, H.
Deposit date:2008-06-26
Release date:2008-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy
J.Biol.Chem., 284, 2009
4C4X
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH C9
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 3-(3,4-dichlorophenyl)-1,1-dimethyl-urea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4C4Y
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH A4
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 1-(3-chlorophenyl)-3-(2-methoxyethyl)urea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4C4Z
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH A8
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 1-ethyl-3-naphthalen-1-ylurea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
6HN4
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LEUCINE-ZIPPERED HUMAN INSULIN RECEPTOR ECTODOMAIN WITH SINGLE BOUND INSULIN - "LOWER" MEMBRANE-PROXIMAL PART
Descriptor:Insulin receptor,Insulin receptor,General control protein GCN4, N-ACETYL-D-GLUCOSAMINE
Authors:Weis, F., Menting, J.G., Margetts, M.B., Chan, S.J., Xu, Y., Tennagels, N., Wohlfart, P., Langer, T., Mueller, C.W., Dreyer, M.K., Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
6HN5
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LEUCINE-ZIPPERED HUMAN INSULIN RECEPTOR ECTODOMAIN WITH SINGLE BOUND INSULIN - "UPPER" MEMBRANE-DISTAL PART
Descriptor:Insulin, Insulin receptor,General control protein GCN4, N-ACETYL-D-GLUCOSAMINE
Authors:Weis, F., Menting, J.G., Margetts, M.B., Chan, S.J., Xu, Y., Tennagels, N., Wohlfart, P., Langer, T., Mueller, C.W., Dreyer, M.K., Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
4XZS
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CRYSTAL STRUCTURE OF TRIAP1-MBP FUSION
Descriptor:Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, ALPHA-D-GLUCOSE
Authors:Miliara, X., Garnett, J.A., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J.
Deposit date:2015-02-04
Release date:2016-01-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
Embo Rep., 16, 2015
4XZV
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CRYSTAL STRUCTURE OF SLMO1-TRIAP1 COMPLEX
Descriptor:Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, Protein slowmo homolog 1, ALPHA-D-GLUCOSE
Authors:Miliara, X., Garnett, J.A., Matthews, S.J.
Deposit date:2015-02-05
Release date:2016-01-20
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
Embo Rep., 16, 2015
6I3V
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X-RAY STRUCTURE OF THE HUMAN MITOCHONDRIAL PRELID1 IN COMPLEX WITH TRIAP1
Descriptor:PRELI domain-containing protein 1, mitochondrial, TP53-regulated inhibitor of apoptosis 1, ...
Authors:Berry, J.L., Miliara, X., Morgan, R.M.L., Matthews, S.J.
Deposit date:2018-11-07
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Nat Commun, 10, 2019
6I3Y
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CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL PRELID1K58V-TRIAP1 COMPLEX WITH PS
Descriptor:PRELI domain-containing protein 1, mitochondrial, TP53-regulated inhibitor of apoptosis 1, ...
Authors:Miliara, X., Berry, J.-L., Morgan, R.M.L., Matthews, S.J.
Deposit date:2018-11-08
Release date:2019-03-20
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Nat Commun, 10, 2019
6I4Y
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X-RAY STRUCTURE OF THE HUMAN MITOCHONDRIAL PRELID3B-TRIAP1 COMPLEX
Descriptor:Maltose transport system, substrate-binding protein,TP53-regulated inhibitor of apoptosis 1, PRELI domain containing protein 3B, ...
Authors:Miliara, X., Berry, J.-L., Morgan, R.M.L., Matthews, S.J.
Deposit date:2018-11-12
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Nat Commun, 10, 2019
2EWA
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DUAL BINDING MODE OF PYRIDINYLIMIDAZOLE TO MAP KINASE P38
Descriptor:Mitogen-activated protein kinase 14, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
Authors:Delarbre, L., Pouzieux, S., Guilloteau, J.-P., Michot, N.
Deposit date:2005-11-02
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:NMR characterization of kinase p38 dynamics in free and ligand-bound forms.
Angew.Chem.Int.Ed.Engl., 45, 2006
2W0G
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HSP90 CO-CHAPERONE CDC37
Descriptor:HSP90 CO-CHAPERONE CDC37
Authors:Sreeramulu, S., Jonker, H.R.A., Schwalbe, H., Lancaster, C.R.D.
Deposit date:2008-08-15
Release date:2008-12-09
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The Human Cdc37.Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy.
J.Biol.Chem., 284, 2009
4YXR
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CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH INHIBITOR.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 3-methyl-2H-indazole
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-27
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4YXS
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CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITH PKI-5-24
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-BENZYL-9H-PURIN-6-AMINE
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-20
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
5XVK
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CRYSTAL STRUCTURE OF MOUSE NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) BOUND WITH END PRODUCT, 1-METHYL NICOTINAMIDE (MNA)
Descriptor:Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 3-carbamoyl-1-methylpyridin-1-ium, ...
Authors:Swaminathan, S., Birudukota, S., Thakur, M.K., Parveen, R., Kandan, S., Kannt, A., Gosu, R.
Deposit date:2017-06-28
Release date:2017-08-02
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochem. Biophys. Res. Commun., 491, 2017
5XVQ
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CRYSTAL STRUCTURE OF MONKEY NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) BOUND WITH END PRODUCT, 1-METHYL NICOTINAMIDE (MNA)
Descriptor:Nicotinamide N-methyltransferase (NNMT), S-ADENOSYL-L-HOMOCYSTEINE, 1-methylpyridine-3-carboxamide, ...
Authors:Birudukota, S., Swaminathan, S., Thakur, M.K., Parveen, R., Kandan, S., Kannt, A., Gosu, R.
Deposit date:2017-06-28
Release date:2017-08-02
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochem. Biophys. Res. Commun., 491, 2017