5XVQ

Crystal structure of monkey Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)

Summary for 5XVQ

Entry DOI	10.2210/pdb5xvq/pdb
Descriptor	Nicotinamide N-methyltransferase (NNMT), S-ADENOSYL-L-HOMOCYSTEINE, 3-carbamoyl-1-methylpyridin-1-ium, ... (5 entities in total)
Functional Keywords	nnmt, mna, ternary complex, feedback inhibition, t2d, transferase
Biological source	Macaca mulatta (Rhesus macaque)
Total number of polymer chains	2
Total formula weight	65072.32
Authors	Birudukota, S.,Swaminathan, S.,Thakur, M.K.,Parveen, R.,Kandan, S.,Kannt, A.,Gosu, R. (deposition date: 2017-06-28, release date: 2017-08-02, Last modification date: 2023-11-22)
Primary citation	Swaminathan, S.,Birudukota, S.,Thakur, M.K.,Parveen, R.,Kandan, S.,Juluri, S.,Shaik, S.,Anand, N.N.,Burri, R.R.,Kristam, R.,Hallur, M.S.,Rajagopal, S.,Schreuder, H.,Langer, T.,Rudolph, C.,Ruf, S.,Dhakshinamoorthy, S.,Gosu, R.,Kannt, A. Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide Biochem. Biophys. Res. Commun., 491:416-422, 2017 Cited by PubMed: 28720493 DOI: 10.1016/j.bbrc.2017.07.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation