4LQ6 | | CRYSTAL STRUCTURE OF RV3717 REVEALS A NOVEL AMIDASE FROM M. TUBERCULOSIS | | Descriptor: | N-acetymuramyl-L-alanine amidase-related protein, ZINC ION, SULFATE ION, ... | | Authors: | Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B. | | Deposit date: | 2013-07-17 | | Release date: | 2013-12-04 | | Last modified: | 2014-01-15 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 69, 2013
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3KJZ | | CRYSTAL STRUCTURE OF NATIVE PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS | | Descriptor: | Peptidyl-tRNA hydrolase | | Authors: | Kumar, A., Singh, N., Yadav, R., Prem Kumar, R., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2009-11-04 | | Release date: | 2010-08-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of Fully-Folded Native and Partially-Folded Intermediate States of Peptidyl-tRNA Hydrolase from Mycobacterium smegmatis
To be Published
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4L69 | |
1JYM | | CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN | | Descriptor: | Peptide Deformylase, COBALT (II) ION | | Authors: | Kumar, A., Nguyen, K.T., Srivathsan, S., Ornstein, B., Turley, S., Hirsh, I., Pei, D., Hol, W.G.J. | | Deposit date: | 2001-09-12 | | Release date: | 2002-03-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design.
Structure, 10, 2002
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3P2J | | CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS AT 2.2 A RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase | | Authors: | Kumar, A., Singh, A., Yadav, R., Sinha, M., Arora, A., Sharma, S., Singh, T.P. | | Deposit date: | 2010-10-02 | | Release date: | 2010-11-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Crystal Structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis at 2.2 A resolution
To be Published
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4DHW | | CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH ADIPIC ACID AT 2.4 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase, hexanedioic acid | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-01-30 | | Release date: | 2012-02-29 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Adipic acid at 2.4 Angstrom resolution
To be Published
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4DJJ | | CRYSTAL STRUCTURE OF THE COMPLEX OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH PIMELIC ACID AT 2.9 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase, PIMELIC ACID | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-02-02 | | Release date: | 2012-03-07 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Crystal structure of the complex of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Pimelic acid at 2.9 Angstrom resolution
To be Published
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4ERX | | CRYSTAL STRUCTURE OF THE COMPLEX OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH DIETHYLENE GLYCOL AT 2.5 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase, DI(HYDROXYETHYL)ETHER | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-04-21 | | Release date: | 2012-05-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the complex of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with diethylene glycol at 2.5 Angstrom resolution
To be Published
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2M5R | |
2N6C | |
3KK0 | | CRYSTAL STRUCTURE OF PARTIALLY FOLDED INTERMEDIATE STATE OF PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS | | Descriptor: | Peptidyl-tRNA hydrolase, ISOPROPYL ALCOHOL, 1,2-ETHANEDIOL, ... | | Authors: | Kumar, A., Singh, N., Yadav, R., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2009-11-04 | | Release date: | 2010-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structures of Fully-Folded Native and Partially-Folded Intermediate States of Peptidyl-tRNA Hydrolase from Mycobacterium smegmatis
To be Published
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5C1Z | | PARKIN (UBLR0RBR) | | Descriptor: | E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ... | | Authors: | kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H. | | Deposit date: | 2015-06-15 | | Release date: | 2015-07-29 | | Last modified: | 2015-10-28 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
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5C23 | | PARKIN (S65DUBLR0RBR) | | Descriptor: | E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ... | | Authors: | Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H. | | Deposit date: | 2015-06-15 | | Release date: | 2015-07-29 | | Last modified: | 2015-10-28 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
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5N2W | | WT-PARKIN AND PUB COMPLEX | | Descriptor: | E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION, ... | | Authors: | Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5N38 | | S65DPARKIN AND PUB COMPLEX | | Descriptor: | E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5N74 | | MICROTUBULE END BINDING PROTEIN COMPLEX | | Descriptor: | Uncharacterized protein, GLY-SER-THR-ARG-ARG-ARG-THR-ARG-LEU-ARG-PRO-PRO-THR-PRO-LEU-SER-GLN-LEU-LEU-SER-PRO | | Authors: | Kumar, A., Steinmetz, M. | | Deposit date: | 2017-02-18 | | Release date: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.
Structure, 25, 2017
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5XPQ | | CRYSTAL STRUCTURE OF M.TUBERCULOSIS RV0081 | | Descriptor: | Uncharacterized HTH-type transcriptional regulator Rv0081 | | Authors: | Kumar, A., Phulera, S., Mande, C.S. | | Deposit date: | 2017-06-04 | | Release date: | 2018-06-06 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of the Rv0081 protein from Mycobacterium tuberculosis suggests a potential mode of transcriptional regulation under hypoxic condition
To Be Published
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1CEH | | STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER | | Descriptor: | PHOSPHOLIPASE A2, CALCIUM ION | | Authors: | Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C.M., Zhu, H., Tsai, M.-D., Sundaralingam, M. | | Deposit date: | 1994-11-16 | | Release date: | 1995-02-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Protein Sci., 3, 1994
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1HXI | | AN UNEXPECTED EXTENDED CONFORMATION FOR THE THIRD TPR MOTIF OF THE PEROXIN PEX5 FROM TRYPANOSOMA BRUCEI | | Descriptor: | PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5, MAGNESIUM ION | | Authors: | Kumar, A., Roach, C., Hirsh, I.S., Turley, S., deWalque, S., Michels, P.A.M., Hol, W.G.J. | | Deposit date: | 2001-01-15 | | Release date: | 2001-03-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
J.Mol.Biol., 307, 2001
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1YWV | | CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-18 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXS | | CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXT | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXU | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, ADENOSINE MONOPHOSPHATE | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXV | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXX | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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