4LQ6 | | CRYSTAL STRUCTURE OF RV3717 REVEALS A NOVEL AMIDASE FROM M. TUBERCULOSIS | | Descriptor: | N-acetymuramyl-L-alanine amidase-related protein | | Authors: | Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B. | | Deposit date: | 2013-07-17 | | Release date: | 2013-12-04 | | Last modified: | 2014-01-15 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 69, 2013
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3KJZ | | CRYSTAL STRUCTURE OF NATIVE PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, N., Yadav, R., Prem Kumar, R., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2009-11-04 | | Release date: | 2010-08-18 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of Fully-Folded Native and Partially-Folded Intermediate States of Peptidyl-tRNA Hydrolase from Mycobacterium smegmatis
To be Published
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4L69 | |
1JYM | | CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN | | Descriptor: | peptide deformylase | | Authors: | Kumar, A., Nguyen, K.T., Srivathsan, S., Ornstein, B., Turley, S., Hirsh, I., Pei, D., Hol, W.G.J. | | Deposit date: | 2001-09-12 | | Release date: | 2002-03-13 | | Last modified: | 2009-02-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design.
Structure, 10, 2002
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3P2J | | CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS AT 2.2 A RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, A., Yadav, R., Sinha, M., Arora, A., Sharma, S., Singh, T.P. | | Deposit date: | 2010-10-02 | | Release date: | 2010-11-17 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Crystal Structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis at 2.2 A resolution
To be Published
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4DHW | | CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH ADIPIC ACID AT 2.4 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-01-30 | | Release date: | 2012-02-29 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Adipic acid at 2.4 Angstrom resolution
To be Published
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4DJJ | | CRYSTAL STRUCTURE OF THE COMPLEX OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH PIMELIC ACID AT 2.9 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-02-02 | | Release date: | 2012-03-07 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Crystal structure of the complex of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with Pimelic acid at 2.9 Angstrom resolution
To be Published
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4ERX | | CRYSTAL STRUCTURE OF THE COMPLEX OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH DIETHYLENE GLYCOL AT 2.5 ANGSTROM RESOLUTION | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, A., Singh, N., Sinha, M., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2012-04-21 | | Release date: | 2012-05-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the complex of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa with diethylene glycol at 2.5 Angstrom resolution
To be Published
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2M5R | |
2N6C | |
3KK0 | | CRYSTAL STRUCTURE OF PARTIALLY FOLDED INTERMEDIATE STATE OF PEPTIDYL-TRNA HYDROLASE FROM MYCOBACTERIUM SMEGMATIS | | Descriptor: | Peptidyl-tRNA hydrolase (E.C.3.1.1.29) | | Authors: | Kumar, A., Singh, N., Yadav, R., Sharma, S., Arora, A., Singh, T.P. | | Deposit date: | 2009-11-04 | | Release date: | 2010-11-10 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structures of Fully-Folded Native and Partially-Folded Intermediate States of Peptidyl-tRNA Hydrolase from Mycobacterium smegmatis
To be Published
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5C1Z | | PARKIN (UBLR0RBR) | | Descriptor: | E3 ubiquitin-protein ligase parkin (E.C.6.3.2.-) | | Authors: | kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H. | | Deposit date: | 2015-06-15 | | Release date: | 2015-07-29 | | Last modified: | 2015-10-28 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
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5C23 | | PARKIN (S65DUBLR0RBR) | | Descriptor: | E3 ubiquitin-protein ligase parkin (E.C.6.3.2.-) | | Authors: | Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H. | | Deposit date: | 2015-06-15 | | Release date: | 2015-07-29 | | Last modified: | 2015-10-28 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
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5N2W | | WT-PARKIN AND PUB COMPLEX | | Descriptor: | E3 ubiquitin-protein ligase parkin (E.C.2.3.2.-), Polyubiquitin-B | | Authors: | Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5N38 | | S65DPARKIN AND PUB COMPLEX | | Descriptor: | PARK2 splice variant, E3 ubiquitin-protein ligase parkin (E.C.2.3.2.-), Polyubiquitin-B | | Authors: | Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5N74 | |
1CEH | | STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER | | Descriptor: | PHOSPHOLIPASE A2 (PLA2) (E.C.3.1.1.4) MUTANT WITH ASP 99 REPLACED BY ASN (D99N) | | Authors: | Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C.M., Zhu, H., Tsai, M.-D., Sundaralingam, M. | | Deposit date: | 1994-11-16 | | Release date: | 1995-02-07 | | Last modified: | 2009-02-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Protein Sci., 3, 1994
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1HXI | | AN UNEXPECTED EXTENDED CONFORMATION FOR THE THIRD TPR MOTIF OF THE PEROXIN PEX5 FROM TRYPANOSOMA BRUCEI | | Descriptor: | PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5 | | Authors: | Kumar, A., Roach, C., Hirsh, I.S., Turley, S., deWalque, S., Michels, P.A.M., Hol, W.G.J. | | Deposit date: | 2001-01-15 | | Release date: | 2001-03-21 | | Last modified: | 2009-02-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
J.Mol.Biol., 307, 2001
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1YWV | | CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-18 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXS | | CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXT | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXU | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXV | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXX | | CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 (E.C.2.7.1.37) | | Authors: | Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2015-06-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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2IQ6 | | CRYSTAL STRUCTURE OF THE AMINOPEPTIDASE FROM VIBRIO PROTEOLYTICUS IN COMPLEXATION WITH LEUCYL-LEUCYL-LEUCINE. | | Descriptor: | Bacterial leucyl aminopeptidase (E.C.3.4.11.10), Leucyl-leucyl-leucine | | Authors: | Kumar, A., Narayanan, B., Kim, J.-J.P., Bennett, B. | | Deposit date: | 2006-10-13 | | Release date: | 2007-08-28 | | Last modified: | 2009-02-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Experimental evidence for a metallohydrolase mechanism in which the nucleophile is not delivered by a metal ion: EPR spectrokinetic and structural studies of aminopeptidase from Vibrio proteolyticus
Biochem.J., 403, 2007
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