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2IJ0
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BU of 2ij0 by Molmil
Structural basis of T cell specificity and activation by the bacterial superantigen toxic shock syndrome toxin-1
Descriptor: Toxic shock syndrome toxin-1, penultimate affinity-matured variant of hVbeta 2.1, D10
Authors:Moza, B, Varma, A.K, Buonpane, R.A, Zhu, P, Herfst, C.A, Nicholson, M.J, Wilbuer, A.K, Nulifer, S, Wucherpfenning, K.W, McCormick, J.K, Kranz, D.M, Sundberg, E.J.
Deposit date:2006-09-28
Release date:2007-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.
Embo J., 26, 2007
3TFK
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BU of 3tfk by Molmil
42F3-p4B10/H2-Ld
Descriptor: 42F3 alpha, 42F3 beta, H2-Ld SBM2, ...
Authors:Adams, J.J, Kranz, D.M, Garcia, K.C.
Deposit date:2011-08-15
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.753 Å)
Cite:T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Immunity, 35, 2011
3TF7
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BU of 3tf7 by Molmil
42F3 QL9/H2-Ld complex
Descriptor: 42F3 Mut7 scFv (42F3 alpha chain, linker, 42F3 beta chain), ...
Authors:Adams, J.J, Kranz, D.M, Garcia, K.C.
Deposit date:2011-08-15
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Immunity, 35, 2011
3TJH
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BU of 3tjh by Molmil
42F3-p3A1/H2-Ld complex
Descriptor: 42F3 alpha, 42F3 beta, H2-Ld SBM2, ...
Authors:Adams, J.J, Kruse, A, Kranz, D.M, Garcia, K.C.
Deposit date:2011-08-24
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Immunity, 35, 2011
3TPU
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BU of 3tpu by Molmil
42F3 p5E8/H2-Ld complex
Descriptor: 1,2-ETHANEDIOL, 42F3 alpha, 42F3 beta, ...
Authors:Adams, J.J, Kranz, D.M, Garcia, K.C.
Deposit date:2011-09-08
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Immunity, 35, 2011
2AQ3
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BU of 2aq3 by Molmil
Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3
Descriptor: Enterotoxin type C-3, T-cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-17
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APB
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BU of 2apb by Molmil
Crystal Structure of the S54N variant of murine T cell receptor Vbeta 8.2 domain
Descriptor: MALONIC ACID, T-cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APX
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BU of 2apx by Molmil
Crystal Structure of the G17E/A52V/S54N/K66E/Q72H/E80V/L81S/T87S/G96V variant of the murine T cell receptor V beta 8.2 domain
Descriptor: MALONIC ACID, T cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2AQ2
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BU of 2aq2 by Molmil
Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3 mutant
Descriptor: Enterotoxin type C-3, SODIUM ION, SULFATE ION, ...
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-17
Release date:2006-03-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APW
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BU of 2apw by Molmil
Crystal Structure of the G17E/A52V/S54N/K66E/E80V/L81S/T87S/G96V variant of the murine T cell receptor V beta 8.2 domain
Descriptor: MALONIC ACID, T cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APV
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BU of 2apv by Molmil
Crystal Structure of the G17E/A52V/S54N/Q72H/E80V/L81S/T87S/G96V variant of the murine T cell receptor V beta 8.2 domain
Descriptor: MALONIC ACID, T cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2AQ1
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BU of 2aq1 by Molmil
Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3 mutant
Descriptor: Enterotoxin type C-3, T-cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-17
Release date:2006-03-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APF
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BU of 2apf by Molmil
Crystal Structure of the A52V/S54N/K66E variant of the murine T cell receptor V beta 8.2 domain
Descriptor: MALONIC ACID, T cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
2APT
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BU of 2apt by Molmil
Crystal Structure of the G17E/S54N/K66E/Q72H/E80V/L81S/T87S/G96V variant of the murine T cell receptor V beta 8.2 domain
Descriptor: MALONIC ACID, T-cell receptor beta chain V
Authors:Cho, S, Swaminathan, C.P, Yang, J, Kerzic, M.C, Guan, R, Kieke, M.C, Kranz, D.M, Mariuzza, R.A, Sundberg, E.J.
Deposit date:2005-08-16
Release date:2006-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure, 13, 2005
6UZ1
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BU of 6uz1 by Molmil
Noncanonical binding of single-chain A6 TCR variant S3-4 in complex with Tax/HLA-A2
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL, ...
Authors:Ma, J, Singh, N.K.
Deposit date:2019-11-14
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
Biochemistry, 59, 2020
5E9D
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BU of 5e9d by Molmil
RD-1 Mart-1 High bound to Mart-1 decameric peptide (ELA) in complex with HLA-A2
Descriptor: A6-TCR Valpha, A6-TCR Vbeta, Beta-2-microglobulin, ...
Authors:Singh, N.K, Baker, B.M.
Deposit date:2015-10-15
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.
Structure, 24, 2016
2ICW
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BU of 2icw by Molmil
Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Wang, L, Zhao, Y, Li, H.
Deposit date:2006-09-13
Release date:2007-03-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
Nat.Struct.Mol.Biol., 14, 2007
1P4L
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BU of 1p4l by Molmil
Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb
Descriptor: Beta-2-microglobulin, LY49-C, MHC CLASS I H-2KB HEAVY CHAIN, ...
Authors:Dam, J, Guan, R, Natarajan, K, Dimasi, N, Mariuzza, R.A.
Deposit date:2003-04-23
Release date:2003-11-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).
Nat.Immunol., 4, 2003
1P1Z
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BU of 1p1z by Molmil
X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb
Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ...
Authors:Dimasi, N, Natarajan, K, Rangjin, G, Dam, J, Margulies, D.H, Mariuzza, R.A.
Deposit date:2003-04-14
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).
Nat.Immunol., 4, 2003
2OI9
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BU of 2oi9 by Molmil
Structure of the 2C/Ld/QL9 allogeneic complex
Descriptor: Major Histocompatibility Complex protein, T cell receptor alpha chain, T cell receptor beta chain, ...
Authors:Garcia, K.C, Colf, L.A.
Deposit date:2007-01-10
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:How a single T cell receptor recognizes both self and foreign MHC.
Cell(Cambridge,Mass.), 129, 2007
3BVG
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BU of 3bvg by Molmil
Manipulating the coupled folding and binding process drives affinity maturation in a protein-protein complex
Descriptor: Enterotoxin type C-3, ZINC ION
Authors:Cho, S, Eric, J.S.
Deposit date:2008-01-07
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Assessing energetic contributions to binding from a disordered region in a protein-protein interaction
Biochemistry, 49, 2010
3E2H
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BU of 3e2h by Molmil
Structure of the m67 high-affinity mutant of the 2C TCR in complex with Ld/QL9
Descriptor: H-2 class I histocompatibility antigen, L-D alpha chain, M67 TCR beta chain, ...
Authors:Colf, L.A, Garcia, K.C.
Deposit date:2008-08-05
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation
J.Immunol., 181, 2008
3E3Q
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BU of 3e3q by Molmil
Structure of the 3alpham13 high-affinity mutant of the 2C TCR in complex with Ld/QL9
Descriptor: H-2 class I histocompatibility antigen, L-D alpha chain, QL9 peptide, ...
Authors:Colf, L.A, Garcia, K.C.
Deposit date:2008-08-07
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.
J.Immunol., 181, 2008
3ERY
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BU of 3ery by Molmil
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors
Descriptor: 2-oxoglutarate dehydrogenase E1 peptide, H-2 class I histocompatibility antigen
Authors:Huang, R.H, Jones, L.L.
Deposit date:2008-10-03
Release date:2008-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors
Biochemistry, 47, 2008
4MS8
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BU of 4ms8 by Molmil
42F3 TCR pCPB9/H-2Ld Complex
Descriptor: 42F3 alpha, 42F3 beta, H-2 class I histocompatibility antigen, ...
Authors:Birnbaum, M.E, Adams, J.J, Garcia, K.C.
Deposit date:2013-09-18
Release date:2014-09-24
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
Nat. Immunol., 17, 2016

 

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