Author results

4ERS
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A MOLECULAR BASIS FOR NEGATIVE REGULATION OF THE GLUCAGON RECEPTOR
Descriptor:Fab light chain, Fab heavy chain, Glucagon receptor, ...
Authors:Murray, J.M., Koth, C.M., Mukund, S.
Deposit date:2012-04-20
Release date:2012-08-29
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.637 Å)
Cite:Molecular basis for negative regulation of the glucagon receptor.
Proc.Natl.Acad.Sci.USA, 109, 2012
1HV2
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SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE
Descriptor:ELONGIN C, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
Authors:Botuyan, M.V., Mer, G., Yi, G.-S., Koth, C.M., Case, D.A., Edwards, A.M., Chazin, W.J., Arrowsmith, C.H.
Deposit date:2001-01-05
Release date:2001-09-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.
J.Mol.Biol., 312, 2001
2BBH
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X-RAY STRUCTURE OF T.MARITIMA CORA SOLUBLE DOMAIN
Descriptor:divalent cation transport-related protein, DECYL-BETA-D-MALTOPYRANOSIDE, SODIUM ION, ...
Authors:Lunin, V.V., Dobrovetsky, E., Khutoreskaya, G., Bochkarev, A., Maguire, M.E., Edwards, A.M., Koth, C.M., Structural Genomics Consortium (SGC)
Deposit date:2005-10-17
Release date:2005-12-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the CorA Mg2+ transporter.
Nature, 440, 2006
2BBJ
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CRYSTAL STRUCTURE OF THE CORA MG2+ TRANSPORTER
Descriptor:divalent cation transport-related protein
Authors:Lunin, V.V., Dobrovetsky, E., Khutoreskaya, G., Zhang, R., Joachimiak, A., Bochkarev, A., Maguire, M.E., Edwards, A.M., Koth, C.M., Structural Genomics Consortium (SGC)
Deposit date:2005-10-17
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structure of the CorA Mg2+ transporter
Nature, 440, 2006
5EK0
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HUMAN NAV1.7-VSD4-NAVAB IN COMPLEX WITH GX-936.
Descriptor:Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
Authors:Ahuja, S., Mukund, S., Starovasnik, M.A., Koth, C.M., Payandeh, J.
Deposit date:2015-11-03
Release date:2015-12-23
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015
6BPL
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E. COLI MSBA IN COMPLEX WITH LPS AND INHIBITOR G907
Descriptor:Lipid A export ATP-binding/permease protein MsbA, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, (2E)-3-{6-[(1S)-1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, ...
Authors:Ho, H., Koth, C.M., Payandeh, J.
Deposit date:2017-11-23
Release date:2018-05-02
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
6BPP
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E. COLI MSBA IN COMPLEX WITH LPS AND INHIBITOR G092
Descriptor:Lipid A export ATP-binding/permease protein MsbA, (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 3-HYDROXY-TETRADECANOIC ACID, ...
Authors:Ho, H., Koth, C.M., Payandeh, J.
Deposit date:2017-11-24
Release date:2018-05-02
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
6N4I
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STRUCTURAL BASIS OF NAV1.7 INHIBITION BY A GATING-MODIFIER SPIDER TOXIN
Descriptor:Nav1.7 VSD2-NavAb channel chimera protein, Beta/omega-theraphotoxin-Tp2a, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Xu, H., Koth, C.M., Payandeh, J.
Deposit date:2018-11-19
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.541 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4Q
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CRYOEM STRUCTURE OF NAV1.7 VSD2 (ACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
Descriptor:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
Authors:Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4R
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CRYOEM STRUCTURE OF NAV1.7 VSD2 (DEACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
Descriptor:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
Authors:Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
3N7P
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CRYSTAL STRUCTURE OF THE ECTODOMAIN COMPLEX OF THE CGRP RECEPTOR, A CLASS-B GPCR, REVEALS THE SITE OF DRUG ANTAGONISM
Descriptor:Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, SULFATE ION
Authors:Ter Haar, E.
Deposit date:2010-05-27
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
Structure, 18, 2010
3N7R
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CRYSTAL STRUCTURE OF THE ECTODOMAIN COMPLEX OF THE CGRP RECEPTOR, A CLASS-B GPCR, REVEALS THE SITE OF DRUG ANTAGONISM
Descriptor:Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ...
Authors:Ter Haar, E.
Deposit date:2010-05-27
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
Structure, 18, 2010
3N7S
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CRYSTAL STRUCTURE OF THE ECTODOMAIN COMPLEX OF THE CGRP RECEPTOR, A CLASS-B GPCR, REVEALS THE SITE OF DRUG ANTAGONISM
Descriptor:Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ...
Authors:Ter Haar, E.
Deposit date:2010-05-27
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
Structure, 18, 2010
4LEX
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UNLIGANDED CRYSTAL STRUCTURE OF MAB7
Descriptor:FAB HEAVY CHAIN, FAB LIGHT CHAIN
Authors:Murray, J.M., Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
4LF3
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INHIBITORY MECHANISM OF AN ALLOSTERIC ANTIBODY TARGETING THE GLUCAGON RECEPTOR
Descriptor:Fab heavy chain, Fab light chain, Glucagon receptor
Authors:Murray, J.M., Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
4LXZ
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STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH SAHA (VORINOSTAT)
Descriptor:Histone deacetylase 2, ZINC ION, CALCIUM ION, ...
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4LY1
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STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH INHIBITOR 4-(ACETYLAMINO)-N-[2-AMINO-5-(THIOPHEN-2-YL)PHENYL]BENZAMIDE
Descriptor:Histone deacetylase 2, ZINC ION, CALCIUM ION, ...
Authors:Fong, R., Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4NNO
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CRYSTAL STRUCTURE OF MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN MNTC FROM STAPHYLOCOCCUS AUREUS BOUND TO A ZINC ION
Descriptor:Lipoprotein, ZINC ION
Authors:Rouge, L., Ahuja, S., Sudhamsu, J.
Deposit date:2013-11-18
Release date:2014-11-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.174 Å)
Cite:CRYSTAL STRUCTURE OF MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN MNTC FROM STAPHYLOCOCCUS AUREUS BOUND TO A ZINC ION
To be Published
4NNP
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CRYSTAL STRUCTURE OF APO MANGANESE ABC TRANSPORTER MNTC FROM STAPHYLOCOCCUS AUREUS BOUND TO AN ANTAGONISTIC FAB FRAGMENT
Descriptor:Lipoprotein, Heavy chain of antagonistic fab fragment, Light chain of antagonistic fab fragment
Authors:Rouge, L., Sudhamsu, J.
Deposit date:2013-11-18
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural Insights into Antibody Inhibition of the Staphylococcus aureus MntABC Mn2+ Import Pathway
To be Published