3N7P

Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism

Summary for 3N7P

• Entry DOI: 10.2210/pdb3n7p/pdb
• Related: 3N7R 3N7S
• Descriptor: Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, SULFATE ION, ... (4 entities in total)
• Functional Keywords: gpcr, class b gpcr, antagonist, olcegepant, telcagepant, migraine, membrane protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: Q16602; Membrane; Single-pass type I membrane protein: O60894
• Total number of polymer chains: 8
• Total formula weight: 99836.53

Authors

Ter Haar, E. (deposition date: 2010-05-27, release date: 2010-09-15, Last modification date: 2017-11-08)

• Primary citation: Ter Haar, E.,Koth, C.M.,Abdul-Manan, N.,Swenson, L.,Coll, J.T.,Lippke, J.A.,Lepre, C.A.,Garcia-Guzman, M.,Moore, J.M.; Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.; Structure, 18:1083-1093, 2010; PubMed: 20826335; DOI: 10.1016/j.str.2010.05.014

Experimental method

X-RAY DIFFRACTION (2.8 Å)