3N7P
Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004948 | molecular_function | calcitonin receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004948 | molecular_function | calcitonin receptor activity |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004930 | molecular_function | G protein-coupled receptor activity |
| C | 0004948 | molecular_function | calcitonin receptor activity |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0016020 | cellular_component | membrane |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| D | 0015026 | molecular_function | coreceptor activity |
| D | 0016020 | cellular_component | membrane |
| E | 0006886 | biological_process | intracellular protein transport |
| E | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| E | 0015026 | molecular_function | coreceptor activity |
| E | 0016020 | cellular_component | membrane |
| F | 0006886 | biological_process | intracellular protein transport |
| F | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| F | 0015026 | molecular_function | coreceptor activity |
| F | 0016020 | cellular_component | membrane |
| J | 0004930 | molecular_function | G protein-coupled receptor activity |
| J | 0004948 | molecular_function | calcitonin receptor activity |
| J | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| J | 0016020 | cellular_component | membrane |
| R | 0006886 | biological_process | intracellular protein transport |
| R | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| R | 0015026 | molecular_function | coreceptor activity |
| R | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | ASP70 |
| A | TRP72 |
| A | THR120 |
| A | TRP121 |
| A | THR122 |
| A | TYR124 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 16 |
| Chain | Residue |
| A | ARG113 |
| D | ASN86 |
| D | ALA87 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 17 |
| Chain | Residue |
| A | CYS74 |
| A | TRP75 |
| A | ASN76 |
| A | GLN86 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| B | ARG119 |
| B | TRP121 |
| D | GLY116 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 12 |
| Chain | Residue |
| B | ARG119 |
| B | THR120 |
| B | THR122 |
| B | TYR124 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 15 |
| Chain | Residue |
| B | ARG113 |
| R | ASN86 |
| R | ALA87 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2 |
| Chain | Residue |
| D | PRO105 |
| D | ILE106 |
| D | SER107 |
| D | GLY108 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 11 |
| Chain | Residue |
| D | ALA70 |
| D | ASP71 |
| D | TRP74 |
| D | TRP84 |
| D | HOH124 |
| R | VAL111 |
| R | ARG112 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 19 |
| Chain | Residue |
| D | ARG64 |
| D | GLU68 |
| R | ARG61 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 4 |
| Chain | Residue |
| E | TRP84 |
| E | PRO85 |
| J | ASP70 |
| J | GLY71 |
| J | TRP72 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 20 |
| Chain | Residue |
| E | ALA70 |
| E | ASP71 |
| E | TRP74 |
| J | MSE42 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 J 1 |
| Chain | Residue |
| J | ARG119 |
| J | THR120 |
| J | TRP121 |
| J | THR122 |
| J | TYR124 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 J 14 |
| Chain | Residue |
| J | HIS114 |
| J | TRP121 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 R 1 |
| Chain | Residue |
| R | PRO105 |
| R | ILE106 |
| R | SER107 |
| R | GLY108 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 R 13 |
| Chain | Residue |
| D | VAL111 |
| D | ARG112 |
| R | ALA70 |
| R | ASP71 |
| R | TRP74 |
| R | TRP84 |
| R | HOH124 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 R 18 |
| Chain | Residue |
| A | TRP121 |
| R | PRO115 |
| R | GLY116 |
| R | SER117 |
Functional Information from PROSITE/UniProt
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWndVaagtesmqlCP |
| Chain | Residue | Details |
| A | CYS65-PRO89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | CYS27-SER117 | |
| J | ASN66 | |
| J | ASN118 | |
| J | ASN123 | |
| E | CYS27-SER117 | |
| F | CYS27-SER117 | |
| R | CYS27-SER117 | |
| B | ASN118 | |
| B | ASN123 | |
| C | ASN66 | |
| C | ASN118 | |
| C | ASN123 |
