7SHV

Crystal structure of BRAF kinase domain bound to GDC0879

Summary for 7SHV

• Entry DOI: 10.2210/pdb7shv/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: kinase, kinase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71401.23

Authors

Kung, J.E.,Sudhamsu, J. (deposition date: 2021-10-11, release date: 2022-10-26, Last modification date: 2023-10-18)

• Primary citation: Chen, X.,Wendorff, T.,Jao, C.,Kung, J.E.,Liau, N.P.D.,Wu, P.,Yu, C.,Oh, A.,Boenig, G.,Wallweber, H.,Everett, C.,Miu, A.,Brillantes, B.,Mortara, K.,Murray, J.,Koth, C.M.,Sudhamsu, J.; Clearing the Path to Rapid High-Quality Protein Purification; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.88 Å)