7SHV
Crystal structure of BRAF kinase domain bound to GDC0879
Summary for 7SHV
Entry DOI | 10.2210/pdb7shv/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | kinase, kinase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71401.23 |
Authors | Kung, J.E.,Sudhamsu, J. (deposition date: 2021-10-11, release date: 2022-10-26, Last modification date: 2023-10-18) |
Primary citation | Chen, X.,Wendorff, T.,Jao, C.,Kung, J.E.,Liau, N.P.D.,Wu, P.,Yu, C.,Oh, A.,Boenig, G.,Wallweber, H.,Everett, C.,Miu, A.,Brillantes, B.,Mortara, K.,Murray, J.,Koth, C.M.,Sudhamsu, J. Clearing the Path to Rapid High-Quality Protein Purification To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
Download full validation report