7SHV
Crystal structure of BRAF kinase domain bound to GDC0879
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 308 | 35330.8 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol | non-polymer | 334.4 | 2 | Chemie (29L) | |||
3 | B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
4 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, B: 432 - 726 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Met 420 | - | initiating methionine |
Asp 421 | - | expression tag |
Arg 422 | - | expression tag |
Gly 423 | - | expression tag |
Ser 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
His 428 | - | expression tag |
His 429 | - | expression tag |
His 430 | - | expression tag |
Gly 431 | - | expression tag |
Leu 727 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70661.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 739.7 | |
All* | Total formula weight | 71401.2 |