3N7R

Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism

Summary for 3N7R

Entry DOI	10.2210/pdb3n7r/pdb
Related	3N7P
Descriptor	Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ... (5 entities in total)
Functional Keywords	gpcr, class b gpcr, antagonist, olcegepant, telcagepant, migraine, membrane protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Multi-pass membrane protein: Q16602 Membrane; Single-pass type I membrane protein: O60894
Total number of polymer chains	4
Total formula weight	50304.56
Authors	Ter Haar, E. (deposition date: 2010-05-27, release date: 2010-09-15, Last modification date: 2022-10-26)
Primary citation	Ter Haar, E.,Koth, C.M.,Abdul-Manan, N.,Swenson, L.,Coll, J.T.,Lippke, J.A.,Lepre, C.A.,Garcia-Guzman, M.,Moore, J.M. Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18:1083-1093, 2010 Cited by PubMed: 20826335 DOI: 10.1016/j.str.2010.05.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation