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1B06
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BU of 1b06 by Molmil
SUPEROXIDE DISMUTASE FROM SULFOLOBUS ACIDOCALDARIUS
Descriptor: FE (III) ION, PROTEIN (SUPEROXIDE DISMUTASE)
Authors:Knapp, S, Kardinahl, S, Niklas, H, Tibbelin, G, Schafer, G, Ladenstein, R.
Deposit date:1998-11-16
Release date:1999-11-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 A resolution.
J.Mol.Biol., 285, 1999
1B26
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BU of 1b26 by Molmil
GLUTAMATE DEHYDROGENASE
Descriptor: GLUTAMATE DEHYDROGENASE
Authors:Knapp, S, Devos, W.M, Rice, D, Ladenstein, R.
Deposit date:1998-12-04
Release date:1999-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 A resolution.
J.Mol.Biol., 267, 1997
1XWS
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BU of 1xws by Molmil
Crystal Structure of the human PIM1 kinase domain
Descriptor: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION
Authors:Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K.
Deposit date:2004-11-02
Release date:2004-11-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human PIM1 kinase domain
To be Published
2BIL
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BU of 2bil by Molmil
The human protein kinase Pim1 in complex with its consensus peptide Pimtide
Descriptor: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1
Authors:Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
2BIK
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BU of 2bik by Molmil
Human Pim1 phosphorylated on Ser261
Descriptor: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1
Authors:Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Pim1 Phosphorylated on Ser261
To be Published
1B3B
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BU of 1b3b by Molmil
THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT N97D, G376K
Descriptor: PROTEIN (GLUTAMATE DEHYDROGENASE)
Authors:Knapp, S, Lebbink, J.H.G, Van Der Oost, J, Devos, W.M, Rice, D, Ladenstein, R.
Deposit date:1998-12-07
Release date:1999-12-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.
J.Mol.Biol., 280, 1998
6QXK
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BU of 6qxk by Molmil
Human PIM1 bound to OX0999
Descriptor: 2-[(1-methylpiperidin-4-yl)methylamino]-5-[[2-[4-(trifluoromethyloxy)phenyl]-1,3-thiazol-4-yl]methyl]-1,3-thiazol-4-one, Pimtide, Serine/threonine-protein kinase pim-1
Authors:Alexander, L.T, Elkins, J.M, Russell, A, Bountra, C, Edwards, A.M, Knapp, S.
Deposit date:2019-03-07
Release date:2019-04-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PIM1 bound to OX0999
To Be Published
2TMG
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BU of 2tmg by Molmil
THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT S128R, T158E, N117R, S160E
Descriptor: PROTEIN (GLUTAMATE DEHYDROGENASE)
Authors:Knapp, S, Lebbink, J.H.G, van der Oost, J, de Vos, W.M, Rice, D, Ladenstein, R.
Deposit date:1998-12-04
Release date:1999-12-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface.
J.Mol.Biol., 289, 1999
4USE
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BU of 4use by Molmil
Human STK10 (LOK) with SB-633825
Descriptor: 4-{5-(6-methoxynaphthalen-2-yl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl}pyridine, SERINE/THREONINE-PROTEIN KINASE 10
Authors:Elkins, J.M, Salah, E, Szklarz, M, von Delft, F, Canning, P, Raynor, J, Bountra, C, Edwards, A.M, Knapp, S.
Deposit date:2014-07-07
Release date:2015-07-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Comprehensive Characterization of the Published Kinase Inhibitor Set.
Nat.Biotechnol., 34, 2016
6FIC
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BU of 6fic by Molmil
Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem
Descriptor: 3-azanyl-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[3-azanyl-1-[[2-[[3-methyl-6-[4-methyl-3-(methylsulfonyl-$l^{2}-azanyl)cyclohexa-1,3,5-trien-1-yl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-$l^{2}-azanyl]-2-oxidanylidene-ethyl]amino]-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-~{N}-[3-[[3-methyl-6-[4-methyl-3-(methylsulfonylamino)phenyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]amino]-3-oxidanylidene-propyl]propanamide, Transcription initiation factor TFIID subunit 1
Authors:Mathea, S, Suh, J.L, Salah, E, Tallant, C, Siejka, P, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, James, L.I, Frye, S.V, Knapp, S.
Deposit date:2018-01-17
Release date:2018-01-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem
To Be Published
3KHF
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BU of 3khf by Molmil
The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Microtubule-associated serine/threonine-protein kinase 3
Authors:Roos, A, Elkins, J, Savitsky, P, Wang, J, Ugochukwu, E, Murray, J, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2009-10-30
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3)
To be Published
1R0P
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BU of 1r0p by Molmil
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Descriptor: Hepatocyte growth factor receptor, K-252A
Authors:Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C.
Deposit date:2003-09-22
Release date:2003-10-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Proc.Natl.Acad.Sci.USA, 100, 2003
4V24
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BU of 4v24 by Molmil
Sphingosine kinase 1 in complex with PF-543
Descriptor: ACETATE ION, SPHINGOSINE KINASE 1, {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL
Authors:Elkins, J.M, Wang, J, Sorrell, F, Tallant, C, Wang, D, Shrestha, L, Bountra, C, von Delft, F, Knapp, S, Edwards, A.
Deposit date:2014-10-05
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Sphingosine Kinase 1 with Pf-543.
Acs Med.Chem.Lett., 5, 2014
4CUP
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BU of 4cup by Molmil
Crystal structure of human BAZ2B in complex with fragment-1 N09421
Descriptor: 4-Fluorobenzamidoxime, BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B, METHANOL
Authors:Bradley, A.R, Liu, Y, Krojer, T, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, von Delft, F.
Deposit date:2014-03-21
Release date:2014-04-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of Human Baz2B in Complex with Fragment-1 N09421
To be Published
7OAJ
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BU of 7oaj by Molmil
Crystal structure of pseudokinase CASK in complex with compound 7
Descriptor: 1,2-ETHANEDIOL, 4-(cyclopentylamino)-2-[(3,4-dichlorophenyl)methylamino]-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAI
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BU of 7oai by Molmil
Crystal structure of pseudokinase CASK in complex with PFE-PKIS12
Descriptor: 1,2-ETHANEDIOL, 4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAK
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BU of 7oak by Molmil
Crystal structure of pseudokinase CASK in complex with compound 26
Descriptor: 1,2-ETHANEDIOL, 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAL
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BU of 7oal by Molmil
Crystal structure of pseudokinase CASK in complex with compound 25
Descriptor: 1,2-ETHANEDIOL, 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclohexylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAM
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BU of 7oam by Molmil
Kinase domain of MERTK in complex with compound 8
Descriptor: 1,2-ETHANEDIOL, 2-[[2,5-bis(fluoranyl)phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide, Tyrosine-protein kinase Mer
Authors:Schroeder, M, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
8RDK
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BU of 8rdk by Molmil
Crystal structure of human Haspin (GSG2) kinase bound to MD420
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-pyridin-4-yl-1~{H}-pyrrolo[3,2-g]isoquinoline, Serine/threonine-protein kinase haspin, ...
Authors:Kraemer, A, Defois, M, Giraud, F, Moreau, P, Anizon, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-12-08
Release date:2024-03-06
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting.
Eur.J.Med.Chem., 276, 2024
4LOO
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BU of 4loo by Molmil
Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Authors:Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
4LOQ
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BU of 4loq by Molmil
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)
Descriptor: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, ...
Authors:Chaikuad, A, DeNicola, G.F, Yue, W.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
4LOP
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BU of 4lop by Molmil
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)
Descriptor: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ...
Authors:Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
2A3K
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BU of 2a3k by Molmil
Crystal Structure of the Human Protein Tyrosine Phosphatase, PTPN7 (HePTP, Hematopoietic Protein Tyrosine Phosphatase)
Descriptor: PHOSPHATE ION, protein tyrosine phosphatase, non-receptor type 7, ...
Authors:Barr, A, Turnbull, A.P, Das, S, Eswaran, J, Debreczeni, J.E, Longmann, E, Smee, C, Burgess, N, Gileadi, O, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2005-06-24
Release date:2005-07-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
7ATS
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BU of 7ats by Molmil
The LIMK1 Kinase Domain Bound To LIJTF500127
Descriptor: LIM domain kinase 1, N-[3-[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide
Authors:Mathea, S, Chatterjee, D, Preuss, F, Yamamoto, S, Tawada, M, Nomura, I, Takagi, T, Ahmed, M, Little, W, Mueller-Knapp, S, Knapp, S.
Deposit date:2020-10-30
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The LIMK1 Kinase Domain Bound To LIJTF500127
To Be Published

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