6FIC

Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem

Summary for 6FIC

• Entry DOI: 10.2210/pdb6fic/pdb
• Descriptor: Transcription initiation factor TFIID subunit 1, 3-azanyl-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[3-azanyl-1-[[2-[[3-methyl-6-[4-methyl-3-(methylsulfonyl-$l^{2}-azanyl)cyclohexa-1,3,5-trien-1-yl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-$l^{2}-azanyl]-2-oxidanylidene-ethyl]amino]-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-~{N}-[3-[[3-methyl-6-[4-methyl-3-(methylsulfonylamino)phenyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]amino]-3-oxidanylidene-propyl]propanamide (3 entities in total)
• Functional Keywords: bromodomain histone binding inhibitor, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36239.98

Authors

Mathea, S.,Suh, J.L.,Salah, E.,Tallant, C.,Siejka, P.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,James, L.I.,Frye, S.V.,Knapp, S. (deposition date: 2018-01-17, release date: 2018-01-31, Last modification date: 2024-01-17)

• Primary citation: Mathea, S.,Suh, J.L.,Salah, E.,Tallant, C.,Siejka, P.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,James, L.I.,Frye, S.V.,Knapp, S.; Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)