7OAM
Kinase domain of MERTK in complex with compound 8
Summary for 7OAM
Entry DOI | 10.2210/pdb7oam/pdb |
Descriptor | Tyrosine-protein kinase Mer, 1,2-ETHANEDIOL, 2-[[2,5-bis(fluoranyl)phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide, ... (4 entities in total) |
Functional Keywords | mertk, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68807.74 |
Authors | Schroeder, M.,Russ, N.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-04-19, release date: 2021-05-19, Last modification date: 2024-01-31) |
Primary citation | Russ, N.,Schroder, M.,Berger, B.T.,Mandel, S.,Aydogan, Y.,Mauer, S.,Pohl, C.,Drewry, D.H.,Chaikuad, A.,Muller, S.,Knapp, S. Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase. J.Med.Chem., 64:14358-14376, 2021 Cited by PubMed: 34543009DOI: 10.1021/acs.jmedchem.1c00845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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