4V24
Sphingosine kinase 1 in complex with PF-543
Summary for 4V24
Entry DOI | 10.2210/pdb4v24/pdb |
Descriptor | SPHINGOSINE KINASE 1, {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL, ACETATE ION, ... (4 entities in total) |
Functional Keywords | transferase, sphk1, sphingosine, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9NYA1 |
Total number of polymer chains | 2 |
Total formula weight | 83328.06 |
Authors | Elkins, J.M.,Wang, J.,Sorrell, F.,Tallant, C.,Wang, D.,Shrestha, L.,Bountra, C.,von Delft, F.,Knapp, S.,Edwards, A. (deposition date: 2014-10-05, release date: 2014-10-15, Last modification date: 2024-01-10) |
Primary citation | Wang, J.,Knapp, S.,Pyne, N.J.,Pyne, S.,Elkins, J.M. Crystal Structure of Sphingosine Kinase 1 with Pf-543. Acs Med.Chem.Lett., 5:1329-, 2014 Cited by PubMed: 25516793DOI: 10.1021/ML5004074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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