4V24
Sphingosine kinase 1 in complex with PF-543
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | SPHINGOSINE KINASE 1 | polymer | 371 | 41168.9 | 2 | UniProt (Q9NYA1) Pfam (PF00781) | HOMO SAPIENS (HUMAN) | |
| 2 | C, E (A, B) | {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL | non-polymer | 465.6 | 2 | Chemie (GYR) | |||
| 3 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
A, B: 87 - 449 (UniProt: Q9NYA1)
| PDB | External Database | Details |
|---|---|---|
| Ser 79 | - | expression tag |
| Met 80 | - | expression tag |
| Glu 81 | - | expression tag |
| Pro 82 | - | expression tag |
| Arg 83 | - | expression tag |
| Val 84 | - | expression tag |
| Glu 85 | - | expression tag |
| Val 86 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82337.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 990.3 | |
| All* | Total formula weight | 83328.1 |
