4LOQ
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)
Summary for 4LOQ
Entry DOI | 10.2210/pdb4loq/pdb |
Descriptor | Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ... (6 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, protein kinase, kinase-regulatory protein complex, mapk, autoactivation, autophosphorylation, transferase |
Biological source | Mus musculus (mouse) More |
Cellular location | Cytoplasm: P47811 |
Total number of polymer chains | 8 |
Total formula weight | 180547.41 |
Authors | Chaikuad, A.,DeNicola, G.F.,Yue, W.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Marber, M.S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-07-13, release date: 2013-08-21, Last modification date: 2023-09-20) |
Primary citation | De Nicola, G.F.,Martin, E.D.,Chaikuad, A.,Bassi, R.,Clark, J.,Martino, L.,Verma, S.,Sicard, P.,Tata, R.,Atkinson, R.A.,Knapp, S.,Conte, M.R.,Marber, M.S. Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20:1182-1190, 2013 Cited by PubMed: 24037507DOI: 10.1038/nsmb.2668 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.319 Å) |
Structure validation
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