4LOQ
Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Mitogen-activated protein kinase 14 | polymer | 361 | 41395.2 | 4 | UniProt (P47811) Pfam (PF00069) In PDB | Mus musculus (mouse) | MAP kinase 14, MAPK 14, CRK1, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha |
| 2 | M, L, K, N | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | polymer | 29 | 3102.5 | 4 | UniProt (Q8CF89) In PDB | Mus musculus | Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1 |
| 3 | A, B, C, D | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE | non-polymer | 338.4 | 4 | Chemie (SB4) | |||
| 4 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 360 (UniProt: P47811)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 177990.9 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2556.5 | |
| All* | Total formula weight | 180547.4 |
