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5G4G
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BU of 5g4g by Molmil
Structure of the ATPgS-bound VAT complex
Descriptor: VCP-LIKE ATPASE
Authors:Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L.
Deposit date:2016-05-12
Release date:2016-07-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
5G4F
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BU of 5g4f by Molmil
Structure of the ADP-bound VAT complex
Descriptor: VCP-LIKE ATPASE
Authors:Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L.
Deposit date:2016-05-12
Release date:2016-07-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
6PVS
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BU of 6pvs by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL320
Descriptor: 9-(5-{[(3R)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)prop-2-yn-1-yl]amino}-5-deoxy-alpha-D-lyxofuranosyl)-9H-purin-6-amine, NNMT protein
Authors:Noinaj, N, Huang, R, Chen, D, Yadav, R.
Deposit date:2019-07-21
Release date:2019-11-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.575 Å)
Cite:Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase.
J.Med.Chem., 62, 2019
6PVE
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BU of 6pve by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319
Descriptor: 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine, NNMT protein
Authors:Noinaj, N, Huang, R, Chen, D, Yadav, R.
Deposit date:2019-07-20
Release date:2019-11-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase.
J.Med.Chem., 62, 2019
8W5K
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BU of 8w5k by Molmil
Cryo-EM structure of the yeast TOM core complex crosslinked by BS3 (from TOM-TIM23 complex)
Descriptor: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, ...
Authors:Wang, Q, Guan, Z.Y, Zhuang, J.J, Huang, R, Yin, P.
Deposit date:2023-08-27
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation.
Cell Discov, 10, 2024
8W5J
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BU of 8w5j by Molmil
Cryo-EM structure of the yeast TOM core complex (from TOM-TIM23 complex)
Descriptor: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, ...
Authors:Wang, Q, Guan, Z.Y, Zhuang, J.J, Huang, R, Yin, P.
Deposit date:2023-08-27
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation.
Cell Discov, 10, 2024
6PVB
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BU of 6pvb by Molmil
The structure of NTMT1 in complex with compound 6
Descriptor: AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2019-07-20
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
6PVA
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BU of 6pva by Molmil
The structure of NTMT1 in complex with compound 11
Descriptor: AMINO GROUP-()-LYSINE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2019-07-20
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The structure of NTMT1 in complex with compound 11
To Be published
6WH8
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BU of 6wh8 by Molmil
The structure of NTMT1 in complex with compound BM-30
Descriptor: 4HP-PRO-LYS-ARG-NH2, BM-30, N-terminal Xaa-Pro-Lys N-methyltransferase 1, ...
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2020-04-07
Release date:2020-08-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.729 Å)
Cite:Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.
J.Med.Chem., 63, 2020
6WJ7
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BU of 6wj7 by Molmil
The structure of NTMT1 in complex with compound C2A
Descriptor: 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, GLY-PRO-LYS-ARG-ILE-ALA-NH2, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Authors:Srinivasan, K, Chen, D, Huang, R, Noinaj, N.
Deposit date:2020-04-13
Release date:2020-08-19
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
8UYS
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BU of 8uys by Molmil
SARS-CoV-2 5' proximal stem-loop 5
Descriptor: SARS-CoV-2 RNA SL5 domain.
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-14
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYJ
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BU of 8uyj by Molmil
BtCoV-HKU5 5' proximal stem-loop 5, conformation 4
Descriptor: BtCoV-HKU5 5' proximal stem-loop 5, conformation 4
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYL
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BU of 8uyl by Molmil
MERS 5' proximal stem-loop 5, conformation 2
Descriptor: MERS 5' proximal stem-loop 5
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYK
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BU of 8uyk by Molmil
MERS 5' proximal stem-loop 5, conformation 1
Descriptor: MERS 5' proximal stem-loop 5
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYM
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BU of 8uym by Molmil
MERS 5' proximal stem-loop 5, conformation 3
Descriptor: MERS 5' proximal stem-loop 5
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYG
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BU of 8uyg by Molmil
BtCoV-HKU5 5' proximal stem-loop 5, conformation 2
Descriptor: RNA (135-MER)
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYE
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BU of 8uye by Molmil
BtCoV-HKU5 5' proximal stem-loop 5, conformation 1
Descriptor: BtCoV-HKU5 5' proximal stem-loop 5
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8UYP
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BU of 8uyp by Molmil
SARS-CoV-1 5' proximal stem-loop 5
Descriptor: SARS-CoV-1 5' proximal stem-loop 5
Authors:Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R.
Deposit date:2023-11-13
Release date:2023-12-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TEX
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BU of 8tex by Molmil
Avian Adeno-associated virus - empty capsid
Descriptor: Capsid protein
Authors:Hsi, J, Mietzsch, M, Chipman, P, Afione, S, Zeher, A, Huang, R, Chiorini, J, McKenna, R.
Deposit date:2023-07-07
Release date:2023-08-30
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structural and antigenic characterization of the avian adeno-associated virus capsid.
J.Virol., 97, 2023
8TEY
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BU of 8tey by Molmil
Avian Adeno-associated virus - empty capsid
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Capsid protein
Authors:Hsi, J, Mietzsch, M, Chipman, P, Afione, S, Zeher, A, Huang, R, Chiorini, J, McKenna, R.
Deposit date:2023-07-07
Release date:2023-08-30
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural and antigenic characterization of the avian adeno-associated virus capsid.
J.Virol., 97, 2023
7RKL
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BU of 7rkl by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (P1 space group)
Descriptor: 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide, NNMT protein, SULFATE ION
Authors:Yadav, R, Noinaj, N, Iyamu, I.D, Huang, R.
Deposit date:2021-07-22
Release date:2022-07-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 61, 2022
7RKK
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BU of 7rkk by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (C2 space group)
Descriptor: 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide, NNMT protein
Authors:Yadav, R, Noinaj, N, Iyamu, I.D, Huang, R.
Deposit date:2021-07-22
Release date:2022-07-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 61, 2022
3LOB
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BU of 3lob by Molmil
Crystal Structure of Flock House Virus calcium mutant
Descriptor: Coat protein beta, Coat protein gamma, RNA (5'-R(*UP*UP*U*AP*UP*CP*UP*(P))-3'), ...
Authors:Johnson, J.E, Banerjee, M, Speir, J.A, Huang, R.
Deposit date:2010-02-03
Release date:2010-04-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate.
J.Virol., 84, 2010
8SHB
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BU of 8shb by Molmil
Crystal Structure of PRMT3 with Compound YD1-208
Descriptor: 5'-S-[3-(N'-phenylcarbamimidamido)propyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3
Authors:Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2023-04-13
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure of PRMT3 with Compound YD1-208
To be published
8SIH
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BU of 8sih by Molmil
Crystal Structure of PRMT4 with Compound YD1-289
Descriptor: 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine, CALCIUM ION, Histone-arginine methyltransferase CARM1
Authors:Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2023-04-16
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of PRMT4 with Compound YD1-289
To be published

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