6PVS

Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL320

Summary for 6PVS

Entry DOI	10.2210/pdb6pvs/pdb
Descriptor	NNMT protein, 9-(5-{[(3R)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)prop-2-yn-1-yl]amino}-5-deoxy-alpha-D-lyxofuranosyl)-9H-purin-6-amine (3 entities in total)
Functional Keywords	methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	127962.25
Authors	Noinaj, N.,Huang, R.,Chen, D.,Yadav, R. (deposition date: 2019-07-21, release date: 2019-11-27, Last modification date: 2024-03-13)
Primary citation	Chen, D.,Li, L.,Diaz, K.,Iyamu, I.D.,Yadav, R.,Noinaj, N.,Huang, R. Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase. J.Med.Chem., 62:10783-10797, 2019 Cited by PubMed: 31724854 DOI: 10.1021/acs.jmedchem.9b01255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.575 Å)

Structure validation