7RKK
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (C2 space group)
Summary for 7RKK
| Entry DOI | 10.2210/pdb7rkk/pdb |
| Descriptor | NNMT protein, 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide (3 entities in total) |
| Functional Keywords | methyltransferase, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 63895.93 |
| Authors | Yadav, R.,Noinaj, N.,Iyamu, I.D.,Huang, R. (deposition date: 2021-07-22, release date: 2022-07-20, Last modification date: 2023-10-18) |
| Primary citation | Iyamu, I.D.,Vilseck, J.Z.,Yadav, R.,Noinaj, N.,Huang, R. Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase. Angew.Chem.Int.Ed.Engl., 61:e202114813-e202114813, 2022 Cited by PubMed: 35134268DOI: 10.1002/anie.202114813 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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