6WH8
The structure of NTMT1 in complex with compound BM-30
Summary for 6WH8
| Entry DOI | 10.2210/pdb6wh8/pdb |
| Related PRD ID | PRD_002315 |
| Descriptor | N-terminal Xaa-Pro-Lys N-methyltransferase 1, 4HP-PRO-LYS-ARG-NH2, BM-30, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
| Functional Keywords | methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 56476.26 |
| Authors | Noinaj, N.,Chen, D.,Huang, R. (deposition date: 2020-04-07, release date: 2020-08-26, Last modification date: 2023-10-18) |
| Primary citation | Mackie, B.D.,Chen, D.,Dong, G.,Dong, C.,Parker, H.,Schaner Tooley, C.E.,Noinaj, N.,Min, J.,Huang, R. Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J.Med.Chem., 63:9512-9522, 2020 Cited by PubMed: 32689795DOI: 10.1021/acs.jmedchem.0c00689 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.729 Å) |
Structure validation
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