6PVB

The structure of NTMT1 in complex with compound 6

Summary for 6PVB

• Entry DOI: 10.2210/pdb6pvb/pdb
• Descriptor: N-terminal Xaa-Pro-Lys N-methyltransferase 1, AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28748.76

Authors

Noinaj, N.,Chen, D.,Huang, R. (deposition date: 2019-07-20, release date: 2020-08-19, Last modification date: 2023-11-15)

• Primary citation: Chen, D.,Dong, C.,Dong, G.,Srinivasan, K.,Min, J.,Noinaj, N.,Huang, R.; Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.; J.Med.Chem., 63:8419-8431, 2020; PubMed: 32605369; DOI: 10.1021/acs.jmedchem.0c00770

Experimental method

X-RAY DIFFRACTION (1.5 Å)