6PVE

Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319

Summary for 6PVE

Entry DOI	10.2210/pdb6pve/pdb
Descriptor	NNMT protein, 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine (3 entities in total)
Functional Keywords	methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	127978.38
Authors	Noinaj, N.,Huang, R.,Chen, D.,Yadav, R. (deposition date: 2019-07-20, release date: 2019-11-27, Last modification date: 2024-03-13)
Primary citation	Chen, D.,Li, L.,Diaz, K.,Iyamu, I.D.,Yadav, R.,Noinaj, N.,Huang, R. Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase. J.Med.Chem., 62:10783-10797, 2019 Cited by PubMed: 31724854 DOI: 10.1021/acs.jmedchem.9b01255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation