6PVE
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319
Summary for 6PVE
Entry DOI | 10.2210/pdb6pve/pdb |
Descriptor | NNMT protein, 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine (3 entities in total) |
Functional Keywords | methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 127978.38 |
Authors | Noinaj, N.,Huang, R.,Chen, D.,Yadav, R. (deposition date: 2019-07-20, release date: 2019-11-27, Last modification date: 2024-03-13) |
Primary citation | Chen, D.,Li, L.,Diaz, K.,Iyamu, I.D.,Yadav, R.,Noinaj, N.,Huang, R. Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase. J.Med.Chem., 62:10783-10797, 2019 Cited by PubMed: 31724854DOI: 10.1021/acs.jmedchem.9b01255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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