Author results

1YRG
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THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN
Descriptor:GTPASE-ACTIVATING PROTEIN RNA1_SCHPO
Authors:Hillig, R.C., Renault, L., Vetter, I.R., Drell, T., Wittinghofer, A., Becker, J.
Deposit date:1999-03-29
Release date:2000-03-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:The crystal structure of rna1p: a new fold for a GTPase-activating protein.
Mol.Cell, 3, 1999
1FZQ
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CRYSTAL STRUCTURE OF MURINE ARL3-GDP
Descriptor:ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3, SULFATE ION, AMMONIUM ION, ...
Authors:Hillig, R.C., Hanzal-Bayer, M., Linari, M., Becker, J., Wittinghofer, A., Renault, L.
Deposit date:2000-10-04
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein.
Structure Fold.Des., 8, 2000
1I4F
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CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Hillig, R.C., Coulie, P.G., Stroobant, V., Saenger, W., Ziegler, A., Huelsmeyer, M.
Deposit date:2001-02-21
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene.
J.Mol.Biol., 310, 2001
1K5D
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CRYSTAL STRUCTURE OF RAN-GPPNHP-RANBP1-RANGAP COMPLEX
Descriptor:GTP-binding nuclear protein RAN, Ran-specific GTPase-activating protein, Ran GTPase activating protein 1, ...
Authors:Seewald, M.J., Koerner, C., Wittinghofer, A., Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
1K5G
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CRYSTAL STRUCTURE OF RAN-GDP-ALFX-RANBP1-RANGAP COMPLEX
Descriptor:GTP-binding nuclear protein RAN, Ran-specific GTPase-activating protein, Ran GTPase activating protein 1, ...
Authors:Seewald, M.J., Koerner, C., Wittinghofer, A., Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
1KSG
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COMPLEX OF ARL2 AND PDE DELTA, CRYSTAL FORM 1
Descriptor:arf-like protein 2, RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT, MAGNESIUM ION, ...
Authors:Hanzal-Bayer, M., Renault, L., Roversi, P., Wittinghofer, A., Hillig, R.C.
Deposit date:2002-01-13
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The complex of Arl2-GTP and PDE delta: from structure to function.
EMBO J., 21, 2002
1KSH
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COMPLEX OF ARL2 AND PDE DELTA, CRYSTAL FORM 2 (NATIVE)
Descriptor:arf-like protein 2, RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT, MAGNESIUM ION, ...
Authors:Hanzal-Bayer, M., Renault, L., Roversi, P., Wittinghofer, A., Hillig, R.C.
Deposit date:2002-01-13
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The complex of Arl2-GTP and PDE delta: from structure to function.
EMBO J., 21, 2002
1KSJ
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COMPLEX OF ARL2 AND PDE DELTA, CRYSTAL FORM 2 (SEMET)
Descriptor:arf-like protein 2, RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT, PHOSPHATE ION, ...
Authors:Hanzal-Bayer, M., Renault, L., Roversi, P., Wittinghofer, A., Hillig, R.C.
Deposit date:2002-01-13
Release date:2002-05-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The complex of Arl2-GTP and PDE delta: from structure to function
EMBO J., 21, 2002
1JGE
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HLA-B*2705 BOUND TO NONA-PEPTIDE M9
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-27 B*2705 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Hulsmeyer, M., Hillig, R.C., Volz, A., Ruhl, M., Schroder, W., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2001-06-25
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations
J.Biol.Chem., 277, 2002
1K5N
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HLA-B*2709 BOUND TO NONA-PEPTIDE M9
Descriptor:major histocompatibility complex molecule HLA-B*2709, beta-2-microglobulin, light chain, ...
Authors:Hulsmeyer, M., Hillig, R.C., Volz, A., Ruhl, M., Schroder, W., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2001-10-11
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural Alterations
J.Biol.Chem., 277, 2002
1JGD
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HLA-B*2709 BOUND TO DECA-PEPTIDE S10R
Descriptor:HUMAN LYMPHOCYTE ANTIGEN HLA-B27, BETA-2-MICROGLOBULIN, peptide s10R, ...
Authors:Hillig, R.C., Huelsmeyer, M., Saenger, W., Volz, A., Uchanska-Ziegler, B., Ziegler, A.
Deposit date:2001-06-25
Release date:2003-07-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Thermodynamic and structural analysis of peptide- and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease association
J.Biol.Chem., 279, 2004
1OF2
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CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408)
Descriptor:HUMAN LYMPHOCYTE ANTIGEN HLA-B27, BETA-2-MICROGLOBULIN, VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR, ...
Authors:Hulsmeyer, M., Fiorillo, M.T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2003-04-04
Release date:2004-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dual, Hla-B27 Subtype-Dependent Conformation of a Self-Peptide
J.Exp.Med., 199, 2004
1OGT
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CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408)
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1, ...
Authors:Hulsmeyer, M., Fiorillo, M.T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2003-05-13
Release date:2004-01-29
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Dual, HLA-B27 subtype-dependent conformation of a self-peptide.
J. Exp. Med., 199, 2004
1W72
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CRYSTAL STRUCTURE OF HLA-A1:MAGE-A1 IN COMPLEX WITH FAB-HYB3
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, MELANOMA-ASSOCIATED ANTIGEN 1, ...
Authors:Hulsmeyer, M., Chames, P., Hillig, R.C., Stanfield, R.L., Held, G., Coulie, P.G., Alings, C., Wille, G., Saenger, W., Uchanska-Ziegler, B., Hoogenboom, H.R., Ziegler, A.
Deposit date:2004-08-27
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Major Histocompatibility Complex.Peptide- Restricted Antibody and T Cell Receptor Molecules Recognize Their Target by Distinct Binding Modes: Crystal Structure of Human Leukocyte Antigen (Hla)-A1.Mage-A1 in Complex with Fab-Hyb3
J.Biol.Chem., 280, 2005
1W0V
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CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE SELF-PEPTIDE TIS FROM EGF-RESPONSE FACTOR 1
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, BUTYRATE RESPONSE FACTOR 2, ...
Authors:Hulsmeyer, M., Fiorillo, M.T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2004-06-14
Release date:2005-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Thermodynamic and Structural Equivalence of Two Hla-B27 Subtypes Complexed with a Self-Peptide
J.Mol.Biol., 346, 2005
1W0W
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CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE SELF-PEPTIDE TIS FROM EGF-RESPONSE FACTOR 1
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, BUTYRATE RESPONSE FACTOR 2, ...
Authors:Hulsmeyer, M., Fiorillo, M.T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2004-06-14
Release date:2005-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Thermodynamic and Structural Equivalence of Two Hla-B27 Subtypes Complexed with a Self-Peptide
J.Mol.Biol., 346, 2005
2CA6
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MIRAS STRUCTURE DETERMINATION FROM HEMIHEDRALLY TWINNED CRYSTALS
Descriptor:RAN GTPASE-ACTIVATING PROTEIN 1, SULFATE ION
Authors:Hillig, R.C., Renault, L.
Deposit date:2005-12-17
Release date:2006-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Detecting and Overcoming Hemihedral Twinning During the Mir Structure Determination of RNA1P.
Acta Crystallogr.,Sect.D, 62, 2006
2JBO
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PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-1, SOAKING)
Descriptor:MAP KINASE-ACTIVATED PROTEIN KINASE 2, PHOSPHATE ION, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Authors:Hillig, R.C., Eberspaecher, U., Monteclaro, F., Huber, M., Nguyen, D., Mengel, A., Muller-Tiemann, B., Egner, U.
Deposit date:2006-12-09
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase Mk2.
J.Mol.Biol., 369, 2007
2JBP
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PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO- CRYSTALLIZATION)
Descriptor:MAP KINASE-ACTIVATED PROTEIN KINASE 2, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Authors:Hillig, R.C., Eberspaecher, U., Monteclaro, F., Huber, M., Nguyen, D., Mengel, A., Muller-Tiemann, B., Egner, U.
Deposit date:2006-12-09
Release date:2007-03-20
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Structural basis for a high affinity inhibitor bound to protein kinase MK2.
J. Mol. Biol., 369, 2007
2JB5
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FAB FRAGMENT IN COMPLEX WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM-1
Descriptor:FAB FRAGMENT MOR03268 HEAVY CHAIN, FAB FRAGMENT MOR03268 LIGHT CHAIN, 2-{(1E,3Z,5E,7E)-7-[3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-1,3-DIHYDRO-2H-INDOL-2-YLIDENE]-4-METHYLHEPTA-1,3,5-TRIEN-1-YL}-3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-3H-INDOLIUM
Authors:Hillig, R.C., Baesler, S., Malawski, G., Badock, V., Bahr, I., Schirner, M., Licha, K.
Deposit date:2006-12-03
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Fab Mor03268 Triggers Absorption Shift of a Diagnostic Dye Via Packaging in a Solvent-Shielded Fab Dimer Interface
J.Mol.Biol., 377, 2008
2JB6
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FAB FRAGMENT IN COMPLEX WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM-2
Descriptor:FAB FRAGMENT MOR03268 LIGHT CHAIN, FAB FRAGMENT MOR03268 HEAVY CHAIN, 2-{(1E,3Z,5E,7E)-7-[3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-1,3-DIHYDRO-2H-INDOL-2-YLIDENE]-4-METHYLHEPTA-1,3,5-TRIEN-1-YL}-3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-3H-INDOLIUM
Authors:Hillig, R.C., Baesler, S., Malawski, G., Badock, V., Bahr, I., Schirner, M., Licha, K.
Deposit date:2006-12-03
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Fab Mor03268 Triggers Absorption Shift of a Diagnostic Dye Via Packaging in a Solvent-Shielded Fab Dimer Interface
J.Mol.Biol., 377, 2008
2V5Q
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CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN
Descriptor:SERINE/THREONINE-PROTEIN KINASE PLK1, DESIGN ANKYRIN REPEAT PROTEIN
Authors:Bandeiras, T.M., Hillig, R.C., Matias, P.M., Eberspaecher, U., Fanghaenel, J., Thomaz, M., Miranda, S., Crusius, K., Puetter, V., Amstutz, P., Gulotti-Georgieva, M., Binz, H.K., Holz, C., Schmitz, A.A.P., Lang, C., Donner, P., Egner, U., Carrondo, M.A., Mueller-Tiemann, B.
Deposit date:2007-07-08
Release date:2008-04-01
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
Acta Crystallogr. D Biol. Crystallogr., 64, 2008
2UZQ
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PROTEIN PHOSPHATASE, NEW CRYSTAL FORM
Descriptor:M-PHASE INDUCER PHOSPHATASE 2, PHOSPHATE ION
Authors:Hillig, R.C., Eberspaecher, U.
Deposit date:2007-05-01
Release date:2008-06-24
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:New Crystal Form of Protein Phosphatase Cdc25B Triggered by Guanidinium Chloride as an Additive
To be Published
3BO8
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THE HIGH RESOLUTION CRYSTAL STRUCTURE OF HLA-A1 COMPLEXED WITH THE MAGE-A1 PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Kumar, P., Vahedi-Faridi, A., Saenger, W., Ziegler, A., Uchanska-Ziegler, B.
Deposit date:2007-12-17
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity
Protein Sci., 18, 2009
2XIX
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PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-1 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN
Descriptor:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3,5-DIAMINO-1H-[1,2,4]TRIAZOLE
Authors:Schulz, M.N., Fanghanel, J., Schafer, M., Badock, V., Briem, H., Boemer, U., Nguyen, D., Husemann, M., Hillig, R.C.
Deposit date:2010-07-01
Release date:2011-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors
Acta Crystallogr.,Sect.D, 67, 2011
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