6EIE

Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations

Summary for 6EIE

Entry DOI	10.2210/pdb6eie/pdb
Descriptor	Son of sevenless homolog 2 (2 entities in total)
Functional Keywords	guanine exchange factor, gef, sos2, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	57370.68
Authors	Hillig, R.C.,Moosmayer, D.,Mastouri, J. (deposition date: 2017-09-19, release date: 2019-02-06, Last modification date: 2024-01-17)
Primary citation	Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Werbeck, N.D.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Mastouri, J.,Petersen, K.,Siemeister, G.,Kahmann, J.D.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116:2551-2560, 2019 Cited by PubMed: 30683722 DOI: 10.1073/pnas.1812963116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.72 Å)

Structure validation