6EIE

Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Son of sevenless homolog 2	polymer	490	57370.7	1	UniProt (Q07890) Pfam (PF00618) Pfam (PF00617)	Homo sapiens (Human)	SOS-2
2	B (A)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 562 - 1047 (UniProt: Q07890)

PDB	External Database	Details
Gly 558	-	expression tag
Ala 559	-	expression tag
Met 560	-	expression tag
Ala 561	-	expression tag
Gln 564	Pro 564	engineered mutation
Tyr 707	Glu 707	engineered mutation
His 768	Gln 768	engineered mutation
Ile 769	Phe 769	engineered mutation
Thr 947	Lys 947	engineered mutation
Arg 948	Lys 948	conflict
His 949	Lys 949	engineered mutation
Pro 1019	Cys 1019	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	57370.7
All*	Total formula weight	57370.7

*Water molecules are not included.