2JBP

Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)

Summary for 2JBP

Related1KWP 1NXK 1NY3 2JBO
DescriptorMAP KINASE-ACTIVATED PROTEIN KINASE 2, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (3 entities in total)
Functional Keywordsser-thr kinase, mapkap kinase 2, phosphorylation, small molecule inhibitor, mk2, kinase, atp site, transferase, atp- binding, serine/threonine-protein kinase, co-crystallization, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains12
Total molecular weight455729.69
Authors
Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U. (deposition date: 2006-12-09, release date: 2007-03-20, Last modification date: 2019-01-16)
Primary citation
Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U.
Structural basis for a high affinity inhibitor bound to protein kinase MK2.
J. Mol. Biol., 369:735-745, 2007
PubMed: 17449059 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.03.004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18541 6.2% 15.2% 5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2jbp
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Molmil generated image of 2jbp
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Molmil generated image of 2jbp
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2jbp
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Molmil generated image of 2jbp
rotated about x axis by 90°
Molmil generated image of 2jbp
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2jbp.pdb7.gz [56.92 KB])
Coordinate files for Biological unit (2jbp.pdb3.gz [56.18 KB])
Coordinate files for Biological unit (2jbp.pdb8.gz [55.63 KB])
Coordinate files for Biological unit (2jbp.pdb6.gz [56.64 KB])
Coordinate files for Biological unit (2jbp.pdb1.gz [55.91 KB])
Coordinate files for Biological unit (2jbp.pdb2.gz [57.18 KB])
Coordinate files for Biological unit (2jbp.pdb11.gz [52.56 KB])
Coordinate files for Biological unit (2jbp.pdb9.gz [56.35 KB])
Coordinate files for Biological unit (2jbp.pdb10.gz [45.31 KB])
Coordinate files for Biological unit (2jbp.pdb12.gz [53.59 KB])
Coordinate files for Biological unit (2jbp.pdb4.gz [56.44 KB])
Coordinate files for Biological unit (2jbp.pdb5.gz [55.79 KB])
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