2JBP

Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)

Summary for 2JBP

Related1KWP 1NXK 1NY3 2JBO
DescriptorMAP KINASE-ACTIVATED PROTEIN KINASE 2, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (3 entities in total)
Functional Keywordsser-thr kinase, mapkap kinase 2, phosphorylation, small molecule inhibitor, mk2, kinase, atp site, transferase, atp- binding, serine/threonine-protein kinase, co-crystallization, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains12
Total molecular weight455729.69
Authors
Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U. (deposition date: 2006-12-09, release date: 2007-03-20, Last modification date: 2019-01-16)
Primary citation
Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U.
Structural basis for a high affinity inhibitor bound to protein kinase MK2.
J. Mol. Biol., 369:735-745, 2007
PubMed: 17449059 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.03.004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18541 6.2% 15.2% 5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload