5OVF

Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 17

Summary for 5OVF

• Entry DOI: 10.2210/pdb5ovf/pdb
• Related: 2II0 5OVD 5OVE 5OVG 5OVH 5OVI
• Descriptor: Son of sevenless homolog 1, 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[3-(1~{H}-pyrazol-4-yl)phenyl]ethyl]quinazolin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: signaling protein, guanine exchange factor, gef, inhibitor, sos1
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 57828.15

Authors

Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Petersen, K.,Kahmann, J.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. (deposition date: 2017-08-28, release date: 2019-02-06, Last modification date: 2019-11-06)

• Primary citation: Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Werbeck, N.D.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Mastouri, J.,Petersen, K.,Siemeister, G.,Kahmann, J.D.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B.; Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.; Proc. Natl. Acad. Sci. U.S.A., 116:2551-2560, 2019; PubMed: 30683722; DOI: 10.1073/pnas.1812963116

Experimental method

X-RAY DIFFRACTION (2.01 Å)