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5OVF

Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 17

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0007264biological_processsmall GTPase-mediated signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue AWT A 1101
ChainResidue
AMET878
AHOH1331
AHOH1345
AASN879
ATYR884
APHE890
ALYS898
ALEU901
AGLU902
AHIS905
AEDO1102

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 1102
ChainResidue
ATYR884
AAWT1101
AHOH1253
AHOH1306

Functional Information from PROSITE/UniProt
site_idPS00720
Number of Residues34
DetailsRASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK
ChainResidueDetails
AVAL927-LYS960

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PDB entries from 2024-07-17

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