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6EG8
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STRUCTURE OF THE GDP-BOUND GS HETEROTRIMER
Descriptor:Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Hilger, D., Liu, X., Aschauer, P., Kobilka, B.K.
Deposit date:2018-08-19
Release date:2019-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell, 177, 2019
4JQI
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STRUCTURE OF ACTIVE BETA-ARRESTIN1 BOUND TO A G PROTEIN-COUPLED RECEPTOR PHOSPHOPEPTIDE
Descriptor:Beta-arrestin-1, Fab30 heavy chain, Fab30 light chain, ...
Authors:Shukla, A.K., Manglik, A., Kruse, A.C., Xiao, K., Reis, R.I., Tseng, W.C., Staus, D.P., Hilger, D., Uysal, S., Huang, L.H., Paduch, M., Shukla, P.T., Koide, A., Koide, S., Weis, W.I., Kossiakoff, A.A., Kobilka, B.K., Lefkowitz, R.J.
Deposit date:2013-03-20
Release date:2013-04-17
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature, 497, 2013
6E67
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STRUCTURE OF BETA2 ADRENERGIC RECEPTOR FUSED TO A GS PEPTIDE
Descriptor:Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Authors:Liu, X., Xu, X., Hilger, D., Tiemann, J., Liu, H., Du, Y., Hirata, K., Sun, X., Guixa-Gonzalez, R., Mathiesen, J., Hildebrand, P., Kobilka, B.
Deposit date:2018-07-24
Release date:2019-06-05
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell, 177, 2019
5VNV
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CRYSTAL STRUCTURE OF NB.B201
Descriptor:Nb.b201, PENTAETHYLENE GLYCOL, POTASSIUM ION, ...
Authors:Kruse, A.C., McMahon, C.
Deposit date:2017-05-01
Release date:2018-02-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Yeast surface display platform for rapid discovery of conformationally selective nanobodies.
Nat. Struct. Mol. Biol., 25, 2018
5VNW
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CRYSTAL STRUCTURE OF NB.B201 BOUND TO HUMAN SERUM ALBUMIN
Descriptor:Serum albumin, Nb.b201, GLYCEROL, ...
Authors:McMahon, C., Kruse, A.C.
Deposit date:2017-05-01
Release date:2018-02-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Yeast surface display platform for rapid discovery of conformationally selective nanobodies.
Nat. Struct. Mol. Biol., 25, 2018
6CRK
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HETEROTRIMERIC G-PROTEIN IN COMPLEX WITH AN ANTIBODY FRAGMENT
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Maeda, S., Dawson, R., Kobilka, B.
Deposit date:2018-03-19
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an antibody fragment that stabilizes GPCR/G-protein complexes.
Nat Commun, 9, 2018
6CSM
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CRYSTAL STRUCTURE OF THE NATURAL LIGHT-GATED ANION CHANNEL GTACR1
Descriptor:GtACR1, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSN
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH8.5
Descriptor:iC++, RETINAL, OLEIC ACID, ...
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSO
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH6.5
Descriptor:iC++, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6DDE
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Zhang, Y., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2018-07-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDF
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2018-07-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
6OS9
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN CANONICAL CONFORMATION (C STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 2019
6OSA
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN NON-CANONICAL CONFORMATION (NC STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 2019