Author results

3P57
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CRYSTAL STRUCTURE OF THE P300 TAZ2 DOMAIN BOUND TO MEF2 ON DNA
分子名称:Myocyte-specific enhancer factor 2A, DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), ...
著者He, J., Ye, J., Riquelme, C., Liu, J.O.
登録日2010-10-08
公開日2011-08-10
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1921 Å)
主引用文献Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
4BH6
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INSIGHTS INTO DEGRON RECOGNITION BY APC COACTIVATORS FROM THE STRUCTURE OF AN ACM1-CDH1 COMPLEX
分子名称:APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1
著者He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D.
登録日2013-03-29
公開日2013-06-05
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013
3RCP
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CRYSTAL STRUCTURE OF THE FAPP1 PLECKSTRIN HOMOLOGY DOMAIN
分子名称:Pleckstrin homology domain-containing family A member 3, GLYCEROL
著者Roy, S., He, J., Kutateladze, T.G.
登録日2011-03-31
公開日2011-04-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
4ADY
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CRYSTAL STRUCTURE OF 26S PROTEASOME SUBUNIT RPN2
分子名称:26S PROTEASOME REGULATORY SUBUNIT RPN2
著者Kulkarni, K., He, J., Da Fonseca, P.C.A., Krutauz, D., Glickman, M.H., Barford, D., Morris, E.P.
登録日2012-01-04
公開日2012-03-14
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
3TI3
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI4
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI5
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI6
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH OSELTAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI8
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIA
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIB
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIC
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
5GZN
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
分子名称:Genome polyprotein, Antibody Heavy chain, Antibody light chain
著者Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
登録日2016-09-29
公開日2016-12-28
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
5GZO
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
分子名称:Genome polyprotein, Antibody heavy chain, Antibody light chain
著者Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
登録日2016-09-29
公開日2017-01-18
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (2.755 Å)
主引用文献Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
3JBM
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ELECTRON CRYO-MICROSCOPY OF A VIRUS-LIKE PARTICLE OF ORANGE-SPOTTED GROUPER NERVOUS NECROSIS VIRUS
分子名称:virus-like particle of orange-spotted grouper nervous necrosis virus
著者Xie, J., Li, K., Gao, Y., Huang, R., Lai, Y., Shi, Y., Yang, S., Zhu, G., Zhang, Q., He, J.
登録日2015-09-06
公開日2016-10-19
最終更新日2017-02-22
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle
Vet. Res., 47, 2016
3MU6
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INHIBITING THE BINDING OF CLASS IIA HISTONE DEACETYLASES TO MYOCYTE ENHANCER FACTOR-2 BY SMALL MOLECULES
分子名称:Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ...
著者Jayathilaka, N., Han, A., Gaffney, K., Dey, R., He, J., Ye, J., Gao, T., Petasis, N.A., Chen, L.
登録日2010-05-01
公開日2011-11-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.434 Å)
主引用文献Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.
Nucleic Acids Res., 40, 2012
4H32
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THE CRYSTAL STRUCTURE OF THE HEMAGGLUTININ H17 DERIVED THE BAT INFLUENZA A VIRUS
分子名称:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE
著者Sun, X., Shi, Y., Lu, X., He, J., Gao, F., Yan, J., Qi, J., Gao, G.F.
登録日2012-09-13
公開日2013-07-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism.
Cell Rep, 3, 2013
4L8Z
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL1
分子名称:Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
著者Li, J., Ren, J., Yang, M., Xiong, B., He, J.
登録日2013-06-18
公開日2014-06-18
実験手法X-RAY DIFFRACTION (1.703 Å)
主引用文献Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4L90
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL3
分子名称:Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](4-methylpiperazin-1-yl)methanone
著者Li, J., Ren, J., Yang, M., Xiong, B., He, J.
登録日2013-06-18
公開日2014-06-18
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Crystal structure of Human Hsp90 with RL3
to be published
4L91
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH X29
分子名称:Heat shock protein HSP 90-alpha, 4-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-chlorobenzene-1,3-diol
著者Li, J., Ren, J., Yang, M., Xiong, B., He, J.
登録日2013-06-18
公開日2014-06-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4L93
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S36
分子名称:Heat shock protein HSP 90-alpha, 3,4-dihydroisoquinolin-2(1H)-yl[2,4-dihydroxy-5-(propan-2-yl)phenyl]methanone
著者Li, J., Ren, J., Yang, M., Xiong, B., He, J.
登録日2013-06-18
公開日2014-06-18
実験手法X-RAY DIFFRACTION (1.845 Å)
主引用文献Crystal structure of Human Hsp90 with S36
To be Published
4L94
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S46
分子名称:Heat shock protein HSP 90-alpha, (4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone
著者Li, J., Ren, J., Yang, M., Xiong, B., He, J.
登録日2013-06-18
公開日2014-06-18
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4LWE
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ2
分子名称:Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide
著者Li, J., Shi, F., Xiong, B., He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2016-10-12
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWF
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ3
分子名称:Heat shock protein HSP 90-alpha, 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol
著者Li, J., Shi, F., Xiong, B., He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2016-10-12
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWG
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ4
分子名称:Heat shock protein HSP 90-alpha, 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
著者Li, J., Shi, F., Xiong, B., He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2016-10-12
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014