3P57 | | CRYSTAL STRUCTURE OF THE P300 TAZ2 DOMAIN BOUND TO MEF2 ON DNA | | 分子名称: | Myocyte-specific enhancer factor 2A, DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), ... | | 著者 | He, J., Ye, J., Riquelme, C., Liu, J.O. | | 登録日 | 2010-10-08 | | 公開日 | 2011-08-10 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.1921 Å) | | 主引用文献 | Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
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4BH6 | | INSIGHTS INTO DEGRON RECOGNITION BY APC COACTIVATORS FROM THE STRUCTURE OF AN ACM1-CDH1 COMPLEX | | 分子名称: | APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1 | | 著者 | He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D. | | 登録日 | 2013-03-29 | | 公開日 | 2013-06-05 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013
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3RCP | |
4ADY | | CRYSTAL STRUCTURE OF 26S PROTEASOME SUBUNIT RPN2 | | 分子名称: | 26S PROTEASOME REGULATORY SUBUNIT RPN2 | | 著者 | Kulkarni, K., He, J., Da Fonseca, P.C.A., Krutauz, D., Glickman, M.H., Barford, D., Morris, E.P. | | 登録日 | 2012-01-04 | | 公開日 | 2012-03-14 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
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5ZGD | | HNRNPA1 REVERSIBLE AMYLOID CORE GFGGNDNFG (RESIDUES 209-217) DETERMINED BY X-RAY | | 分子名称: | GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY | | 著者 | Gui, X., Xie, M., Zhao, M., Luo, F., He, J., Li, D., Liu, C. | | 登録日 | 2018-03-08 | | 公開日 | 2019-04-03 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
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5ZGL | | HNRNP A1 SEGMENT GGGYGGS (RESIDUES 234-240) | | 分子名称: | 7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1 | | 著者 | Xie, M., Luo, F., Gui, X., Zhao, M., He, J., Li, D., Liu, C. | | 登録日 | 2018-03-09 | | 公開日 | 2019-04-03 | | 最終更新日 | 2020-03-04 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
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5GZN | | STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN | | 分子名称: | Genome polyprotein, Antibody Heavy chain, Antibody light chain | | 著者 | Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. | | 登録日 | 2016-09-29 | | 公開日 | 2016-12-28 | | 最終更新日 | 2017-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
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5GZO | | STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN | | 分子名称: | Genome polyprotein, Antibody heavy chain, Antibody light chain | | 著者 | Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. | | 登録日 | 2016-09-29 | | 公開日 | 2017-01-18 | | 最終更新日 | 2017-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
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3TI3 | | CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR | | 分子名称: | Neuraminidase, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TI4 | | CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE | | 分子名称: | Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TI5 | | CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR | | 分子名称: | Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TI6 | | CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH OSELTAMIVIR | | 分子名称: | Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-23 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TI8 | | CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR | | 分子名称: | Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TIA | | CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR | | 分子名称: | Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TIB | | CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE | | 分子名称: | Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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3TIC | | CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR | | 分子名称: | Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ... | | 著者 | Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F. | | 登録日 | 2011-08-20 | | 公開日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
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4H32 | | THE CRYSTAL STRUCTURE OF THE HEMAGGLUTININ H17 DERIVED THE BAT INFLUENZA A VIRUS | | 分子名称: | Hemagglutinin, N-ACETYL-D-GLUCOSAMINE | | 著者 | Sun, X., Shi, Y., Lu, X., He, J., Gao, F., Yan, J., Qi, J., Gao, G.F. | | 登録日 | 2012-09-13 | | 公開日 | 2013-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism.
Cell Rep, 3, 2013
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4L8Z | | CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL1 | | 分子名称: | Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone | | 著者 | Li, J., Ren, J., Yang, M., Xiong, B., He, J. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | | 主引用文献 | Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
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4L90 | | CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL3 | | 分子名称: | Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](4-methylpiperazin-1-yl)methanone | | 著者 | Li, J., Ren, J., Yang, M., Xiong, B., He, J. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Crystal structure of Human Hsp90 with RL3
to be published
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4L91 | | CRYSTAL STRUCTURE OF HUMAN HSP90 WITH X29 | | 分子名称: | Heat shock protein HSP 90-alpha, 4-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-chlorobenzene-1,3-diol | | 著者 | Li, J., Ren, J., Yang, M., Xiong, B., He, J. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
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4L93 | | CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S36 | | 分子名称: | Heat shock protein HSP 90-alpha, 3,4-dihydroisoquinolin-2(1H)-yl[2,4-dihydroxy-5-(propan-2-yl)phenyl]methanone | | 著者 | Li, J., Ren, J., Yang, M., Xiong, B., He, J. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | | 主引用文献 | Crystal structure of Human Hsp90 with S36
To be Published
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4L94 | | CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S46 | | 分子名称: | Heat shock protein HSP 90-alpha, (4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone | | 著者 | Li, J., Ren, J., Yang, M., Xiong, B., He, J. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.649 Å) | | 主引用文献 | Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
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4LWE | | CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ2 | | 分子名称: | Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide | | 著者 | Li, J., Shi, F., Xiong, B., He, J. | | 登録日 | 2013-07-27 | | 公開日 | 2014-07-30 | | 最終更新日 | 2016-10-12 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
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4LWF | | CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ3 | | 分子名称: | Heat shock protein HSP 90-alpha, 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol | | 著者 | Li, J., Shi, F., Xiong, B., He, J. | | 登録日 | 2013-07-27 | | 公開日 | 2014-07-30 | | 最終更新日 | 2016-10-12 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
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4LWG | | CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ4 | | 分子名称: | Heat shock protein HSP 90-alpha, 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone | | 著者 | Li, J., Shi, F., Xiong, B., He, J. | | 登録日 | 2013-07-27 | | 公開日 | 2014-07-30 | | 最終更新日 | 2016-10-12 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
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