7XU6

Structure of SARS-CoV-2 Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), incubated in Low pH after 40-Day Storage in PBS, Locked-2 Conformation

Summary for 7XU6

• Entry DOI: 10.2210/pdb7xu6/pdb
• EMDB information: 33453 33460
• Descriptor: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: protein engineering, spike protein, sars-cov-2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 3
• Total formula weight: 389649.59

Authors

Qu, K.,Chen, Q.,Ciazynska, K.A.,Liu, B.,Zhang, X.,Wang, J.,He, Y.,Guan, J.,He, J.,Liu, T.,Zhang, X.,Carter, A.P.,Xiong, X.,Briggs, J.A.G. (deposition date: 2022-05-18, release date: 2022-07-20, Last modification date: 2022-08-17)

• Primary citation: Qu, K.,Chen, Q.,Ciazynska, K.A.,Liu, B.,Zhang, X.,Wang, J.,He, Y.,Guan, J.,He, J.,Liu, T.,Zhang, X.,Carter, A.P.,Xiong, X.,Briggs, J.A.G.; Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.; Plos Pathog., 18:e1010583-e1010583, 2022; PubMed: 35905112; DOI: 10.1371/journal.ppat.1010583

Experimental method

ELECTRON MICROSCOPY (2.9 Å)