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4L94

Crystal structure of Human Hsp90 with S46

Summary for 4L94
Entry DOI10.2210/pdb4l94/pdb
Related4L8Z 4L90 4L91 4L93
DescriptorHeat shock protein HSP 90-alpha, (4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone (3 entities in total)
Functional Keywordsatp hydrolysis, hsp90n-hsp90n inhibitor complex, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight25877.04
Authors
Li, J.,Ren, J.,Yang, M.,Xiong, B.,He, J. (deposition date: 2013-06-18, release date: 2014-06-18, Last modification date: 2023-11-08)
Primary citationRen, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J.
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24:2525-2529, 2014
Cited by
PubMed: 24751441
DOI: 10.1016/j.bmcl.2014.03.100
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.649 Å)
Structure validation

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