4L8Z
Crystal structure of Human Hsp90 with RL1
Summary for 4L8Z
Entry DOI | 10.2210/pdb4l8z/pdb |
Related | 4L90 4L91 4L93 4L94 |
Descriptor | Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone (3 entities in total) |
Functional Keywords | atp hydrolysis, hsp90n-hsp90n inhibitor complex, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 26122.07 |
Authors | |
Primary citation | Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett., 24:2525-2529, 2014 Cited by PubMed: 24751441DOI: 10.1016/j.bmcl.2014.03.100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.703 Å) |
Structure validation
Download full validation report